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    GSP2 Ran GTPase GSP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GSP2
    Official Full Name
    Ran GTPase GSP2
    Primary source
    SGD:S000005711
    Locus tag
    YOR185C
    See related
    AllianceGenome:SGD:S000005711; FungiDB:YOR185C; VEuPathDB:YOR185C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CNR2
    Summary
    Predicted to enable GTPase activity. Involved in nucleus organization. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GSP2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (681444..682106, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene O-phospho-L-serine:2-oxoglutarate transaminase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene translation elongation factor Tu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Schlenstedt G, et al. Proc Natl Acad Sci U S A, 1995 Jan 3. PMID 7816822, Free PMC Article
    2. A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase. Belhumeur P, et al. Yeast, 1994 Mar. PMID 8017107
    3. Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. Kadowaki T, et al. EMBO J, 1993 Jul. PMID 7687541, Free PMC Article
    4. Role of the nuclear transport factor p10 in nuclear import. Nehrbass U, et al. Science, 1996 Apr 5. PMID 8600522
    5. GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Belhumeur P, et al. Mol Cell Biol, 1993 Apr. PMID 8455603, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ran GTPase GSP2
    NP_014828.1
    • GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      681444..682106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183604.1 → NP_014828.1  TPA: Ran GTPase GSP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2P1, P32836
      UniProtKB/TrEMBL
      A6ZP30, B3LJL5, B5VS69, C7GLQ9, C8ZGU4, G2WN58, N1NVU4
      Conserved Domains (1) summary
      PTZ00132
      Location:5 → 217
      PTZ00132; GTP-binding nuclear protein Ran; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32836.1

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