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    PMA2 H(+)-exporting P2-type ATPase PMA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PMA2
    Official Full Name
    H(+)-exporting P2-type ATPase PMA2
    Primary source
    SGD:S000005957
    Locus tag
    YPL036W
    See related
    AllianceGenome:SGD:S000005957; FungiDB:YPL036W; VEuPathDB:YPL036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables P-type proton-exporting transporter activity. Involved in proton transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PMA2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (482843..485686)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Met31p Neighboring gene Egd1p Neighboring gene uncharacterized protein Neighboring gene Srl4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In-frame recombination between the yeast H(+)-ATPase isogenes PMA1 and PMA2: insights into the mechanism of recombination initiated by a double-strand break. Supply P, et al. Mol Cell Biol, 1995 Oct. PMID 7565689, Free PMC Article
    2. Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. Viegas CA, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 8286419
    3. The ATP binding site of the yeast plasma membrane proton-translocating ATPase. Davis CB, et al. J Biol Chem, 1990 Jan 25. PMID 2136852
    4. Adaptative responses in yeast to the herbicide 2-methyl-4-chlorophenoxyacetic acid at the level of intracellular pH homeostasis. Guadalupe Cabral M, et al. J Appl Microbiol, 2004. PMID 14962141
    5. Transcription patterns of PMA1 and PMA2 genes and activity of plasma membrane H+-ATPase in Saccharomyces cerevisiae during diauxic growth and stationary phase. Fernandes AR, et al. Yeast, 2003 Feb. PMID 12557274

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type proton-exporting transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type proton-exporting transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type proton-exporting transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-exporting P2-type ATPase PMA2
    NP_015289.1
    • Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      482843..485686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183850.1 → NP_015289.1  TPA: H(+)-exporting P2-type ATPase PMA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015289.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3X8, P19657
      UniProtKB/TrEMBL
      A6ZWL2, C7GU18, N1NVZ2
      Conserved Domains (1) summary
      cd02076
      Location:116 → 903
      P-type_ATPase_H; plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19657.3

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