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    DIP5 dicarboxylic amino acid permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP5
    Official Full Name
    dicarboxylic amino acid permease
    Primary source
    SGD:S000006186
    Locus tag
    YPL265W
    See related
    AllianceGenome:SGD:S000006186; FungiDB:YPL265W; VEuPathDB:YPL265W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dicarboxylic acid transmembrane transporter activity. Involved in amino acid transport. Located in fungal-type vacuole membrane and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DIP5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (41043..42869)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Acm1p Neighboring gene putative dimethyladenosine transferase Neighboring gene uncharacterized protein Neighboring gene Kel3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae. Regenberg B, et al. Curr Genet, 1998 Mar. PMID 9508791
    2. Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease. Trip H, et al. Appl Environ Microbiol, 2004 Aug. PMID 15294814, Free PMC Article
    3. Clearance of yeast prions by misfolded multi-transmembrane proteins. Arai C, et al. Biochimie, 2013 Jun. PMID 23384482
    4. Adaptability of the Saccharomyces cerevisiae yeasts to wine fermentation conditions relies on their strong ability to consume nitrogen. Brice C, et al. PLoS One, 2018. PMID 29432462, Free PMC Article
    5. Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae. Rong-Mullins X, et al. PLoS One, 2017. PMID 29155836, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequence comparison between the target proteins, i.e., the plant EPSPS and the yeast orthologous protein Aro1, predicted that yeast would be resistant to glyphosate. However, the growth variation seen in the subset of yeast tested was not due to polymorphisms within Aro1, instead, it was caused by genetic variation in an ABC multiple drug transporter, Pdr5, and an amino acid permease, Dip5
      Title: Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.
    2. Results indicate that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2.
      Title: Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dicarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    dicarboxylic amino acid permease
    NP_015058.1
    • Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      41043..42869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184079.1 → NP_015058.1  TPA: dicarboxylic amino acid permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3A5, P53388
      UniProtKB/TrEMBL
      B3LKG8, B5VSS2, C7GSG5, G2WNS1, N1NVT7
      Conserved Domains (1) summary
      TIGR00913
      Location:83 → 566
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53388.1

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