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    SCM3 Scm3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCM3
    Official Full Name
    Scm3p
    Primary source
    SGD:S000002298
    Locus tag
    YDL139C
    See related
    AllianceGenome:SGD:S000002298; FungiDB:YDL139C; VEuPathDB:YDL139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables CENP-A containing nucleosome binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; kinetochore assembly; and negative regulation of ubiquitin-dependent protein catabolic process. Located in condensed chromosome, centromeric region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCM3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (211375..212046, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene biotin--[acetyl-CoA-carboxylase] ligase BPL1 Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene glucose sensor Neighboring gene Arf family GTPase ARF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domain architectures of the Scm3p protein provide insights into centromere function and evolution. Aravind L, et al. Cell Cycle, 2007 Oct 15. PMID 17704645, Free PMC Article
    2. Common ancestry of the CENP-A chaperones Scm3 and HJURP. Sanchez-Pulido L, et al. Cell, 2009 Jun 26. PMID 19563746, Free PMC Article
    3. Backbone and side-chain resonance assignments of centromeric protein Scm3 from Saccharomyces cerevisiae. Bhattacharya A, et al. Biomol NMR Assign, 2019 Oct. PMID 30937734
    4. Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Stoler S, et al. Proc Natl Acad Sci U S A, 2007 Jun 19. PMID 17548816, Free PMC Article
    5. Cse4 (CenH3) association with the Saccharomyces cerevisiae plasmid partitioning locus in its native and chromosomally integrated states: implications in centromere evolution. Huang CC, et al. Mol Cell Biol, 2011 Mar. PMID 21173161, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cse4 and H3 are structurally compatible to be incorporated in the same nucleosome to form heterotypic particles during Scm3-mediated nucleosome assembly.
      Title: Scm3 deposits a (Cse4-H4)2 tetramer onto DNA through a Cse4-H4 dimer intermediate.
    2. Scm3 becomes 2.5-fold enriched at kinetochores in anaphase after incorporation of Ces4 and then dissociated from kinetochores with mitotic exit.
      Title: The CENP-A chaperone Scm3 becomes enriched at kinetochores in anaphase independently of CENP-A incorporation.
    3. stringent regulation of HJURP and SCM3 expression are critical for genome stability.
      Title: Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.
    4. Scm3 functions as a Cse4-specific nucleosome assembly factor, and the resulting octameric nucleosomes do not contain Scm3 as a stably bound component.
      Title: Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes.
    5. Study propose that Scm3 plays an active role in centromeric nucleosome assembly.
      Title: Scm3 is a centromeric nucleosome assembly factor.
    6. Ndc10/Scm3 binds to centromeric DNA, which is in turn essential for targeting Cse4 to centromeres.
      Title: Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore.
    7. nonhistone Scm3 serves to assemble and maintain Cse4-H4 at centromeres and may replace histone H2A-H2B dimers in a centromere-specific nucleosome core
      Title: Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables CENP-A containing nucleosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables CENP-A containing nucleosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scm3p
    NP_010142.2
    • Non-histone component of centromeric chromatin; acts as a Cse4p specific chaperone that recognizes the centromere-targeting domain in the HFD of histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      211375..212046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180199.1 → NP_010142.2  TPA: Scm3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010142.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK9, Q12334
      UniProtKB/TrEMBL
      C7GKZ1, G2WC22, N1P7V3
      Conserved Domains (1) summary
      pfam10384
      Location:92 → 141
      Scm3; Centromere protein Scm3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12334.2

    Gene LinkOut

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