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    SPC19 Spc19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851782, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPC19
    Official Full Name
    Spc19p
    Primary source
    SGD:S000002609
    Locus tag
    YDR201W
    See related
    AllianceGenome:SGD:S000002609; FungiDB:YDR201W; VEuPathDB:YDR201W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SPC19 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (856317..856814)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene Vps64p Neighboring gene Rav2p Neighboring gene ubiquinone biosynthesis protein COQ4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
    2. Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules. Muir KW, et al. Science, 2023 Dec 8. PMID 38060647, Free PMC Article
    3. A method for reverse interactome analysis: High-resolution mapping of interdomain interaction network in Dam1 complex and its specific disorganization based on the interaction domain expression. Ikeuchi A, et al. Biotechnol Prog, 2010 Jul-Aug. PMID 20730753
    4. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. Cheeseman IM, et al. J Cell Biol, 2001 Dec 24. PMID 11756468, Free PMC Article
    5. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Gestaut DR, et al. Nat Cell Biol, 2008 Apr. PMID 18364702, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc19p
    NP_010487.3
    • Essential subunit of Dam1 complex (aka DASH complex); complex couples kinetochores to force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body; SPC19 mRNA level is reduced when downstream gene RAV2 is deleted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      856317..856814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180509.3 → NP_010487.3  TPA: Spc19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010487.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI3, Q03954
      UniProtKB/TrEMBL
      B3LG83, G2WAU9, N1P6J3
      Conserved Domains (1) summary
      pfam08287
      Location:6 → 129
      DASH_Spc19; Spc19
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03954.1

    Gene LinkOut

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