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    SLY1 syntaxin-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851770, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLY1
    Official Full Name
    syntaxin-binding protein
    Primary source
    SGD:S000002597
    Locus tag
    YDR189W
    See related
    AllianceGenome:SGD:S000002597; FungiDB:YDR189W; VEuPathDB:YDR189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables syntaxin binding activity. Involved in Golgi vesicle transport and positive regulation of SNARE complex assembly. Located in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum. Orthologous to human SCFD1 (sec1 family domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SLY1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (838392..840392)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Snd1p Neighboring gene chaperonin-containing T-complex subunit CCT6 Neighboring gene RuvB family ATP-dependent DNA helicase pontin Neighboring gene NAD-dependent histone deacetylase HST4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms. Duan M, et al. J Cell Biol, 2024 Jun 3. PMID 38478017, Free PMC Article
    2. The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Demircioglu FE, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25189771, Free PMC Article
    3. Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. Bracher A, et al. EMBO J, 2002 Nov 15. PMID 12426383, Free PMC Article
    4. Protein-protein interactions of the yeast Golgi t-SNARE Sed5 protein distinct from its neural plasma membrane cognate syntaxin 1. Kosodo Y, et al. Biochem Biophys Res Commun, 1998 Sep 18. PMID 9753609
    5. Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae. Hou J, et al. Metab Eng, 2012 Mar. PMID 22265825

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms.
      Title: SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms.
    2. Sec17 directly promotes selective loading of Sly1 and Vps33 onto cognate SNARE complexes
      Title: SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18.
    3. In contrast to Munc18, however, Sly1 facilitates SNARE complex formation by loosening the closed conformation of Sed5.
      Title: The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex.
    4. Findings identify Sly1 as a discriminating regulator of SNARE levels and indicate that Sly1-controlled ERAD might regulate the balance between different Qa-SNARE proteins.
      Title: SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
    5. alternative Rab protein satisfies the Ypt1p requirement in Uso1p-dependent tethering when SLY1-20 is expressed
      Title: A Rab requirement is not bypassed in SLY1-20 suppression.
    6. Sly1 plays a vital and previously unrecognized role in retrograde transport to the endoplasmic reticulum.
      Title: Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of SNARE complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein
    NP_010475.1
    • Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      838392..840392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180497.1 → NP_010475.1  TPA: syntaxin-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSH2, P22213
      UniProtKB/TrEMBL
      A6ZYE8, B3LG94, C7GN08, C8Z5A4, G2WAT8
      Conserved Domains (1) summary
      COG5158
      Location:11 → 661
      SEC1; Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22213.1

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