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    TAN1 putative tRNA acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAN1
    Official Full Name
    putative tRNA acetyltransferase
    Primary source
    SGD:S000003201
    Locus tag
    YGL232W
    See related
    AllianceGenome:SGD:S000003201; FungiDB:YGL232W; VEuPathDB:YGL232W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human THUMPD1 (THUMP domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAN1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (62075..63002)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase Neighboring gene Rab GTPase-binding exocyst subunit SEC15 Neighboring gene chaperone EMC4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. Johansson MJ, et al. RNA, 2004 Apr. PMID 15037780, Free PMC Article
    2. Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells. Makise M, et al. Biochem J, 2007 Mar 1. PMID 17107343, Free PMC Article
    3. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Sas-Chen A, et al. Nature, 2020 Jul. PMID 32555463, Free PMC Article
    4. Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response. Sharma S, et al. 3 Biotech, 2017 Jul. PMID 28677085, Free PMC Article
    5. Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. Kotelawala L, et al. RNA, 2008 Jan. PMID 18025252, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative tRNA acetyltransferase
    NP_011282.1
    • Adaptor in Kre33p-mediated N4-acetylcytidine modification of tRNAs; tRNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine (ac4C) in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress; contains a conserved THUMP domain, and is homologous to human THUMPD1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      62075..63002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181098.1 → NP_011282.1  TPA: putative tRNA acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011282.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA2, P53072
      UniProtKB/TrEMBL
      A6ZTV8, B3LHS5, C7GNX9, C8Z823, G2WDM7, N1P9V3
      Conserved Domains (1) summary
      cd11717
      Location:113 → 259
      THUMP_THUMPD1_like; THUMP domain-containing protein 1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53072.1

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