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    TAD1 tRNA-specific adenosine deaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAD1
    Official Full Name
    tRNA-specific adenosine deaminase
    Primary source
    SGD:S000003212
    Locus tag
    YGL243W
    See related
    AllianceGenome:SGD:S000003212; FungiDB:YGL243W; VEuPathDB:YGL243W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA-specific adenosine-37 deaminase activity. Involved in tRNA modification. Located in nucleus. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAD1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (43307..44509)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase GUS1 Neighboring gene Rtf1p Neighboring gene Ank1p Neighboring gene karyopherin KAP114

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. Gerber A, et al. EMBO J, 1998 Aug 17. PMID 9707437, Free PMC Article
    2. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article
    3. A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome. Srikumar T, et al. Mol Syst Biol, 2013 May 28. PMID 23712011, Free PMC Article
    4. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Gallina I, et al. Nat Commun, 2015 Mar 30. PMID 25817432, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine-37 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine-37 deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-specific adenosine-37 deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    tRNA-specific adenosine deaminase
    NP_011271.1
    • tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      43307..44509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181109.1 → NP_011271.1  TPA: tRNA-specific adenosine deaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV92, P53065
      UniProtKB/TrEMBL
      B3LHT5
      Conserved Domains (1) summary
      smart00552
      Location:22 → 400
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53065.1

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