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    APL4 Apl4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APL4
    Official Full Name
    Apl4p
    Primary source
    SGD:S000006233
    Locus tag
    YPR029C
    See related
    AllianceGenome:SGD:S000006233; FungiDB:YPR029C; VEuPathDB:YPR029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables clathrin binding activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Used to study Parkinson's disease. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1) and AP1G2 (adaptor related protein complex 1 subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APL4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (624469..626967, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene Yop1p Neighboring gene Csr2p Neighboring gene Nto1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation-driven transport and AP-1-dependent recycling of a secretory cargo in the Golgi. Casler JC, et al. J Cell Biol, 2019 May 6. PMID 30858194, Free PMC Article
    2. Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats. Yeung BG, et al. Traffic, 2001 Aug. PMID 11489214
    3. Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. Duncan MC, et al. Nat Cell Biol, 2003 Jan. PMID 12483220
    4. A microscopy-based kinetic analysis of yeast vacuolar protein sorting. Casler JC, et al. Elife, 2020 Jun 25. PMID 32584255, Free PMC Article
    5. Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast. Zysnarski CJ, et al. J Biol Chem, 2019 Jan 25. PMID 30523155, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apl4p
    NP_015354.1
    • Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      624469..626967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184126.1 → NP_015354.1  TPA: Apl4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015354.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W439, Q12028
      UniProtKB/TrEMBL
      A6ZWS2, N1NW08
      Conserved Domains (2) summary
      smart00809
      Location:727 → 828
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:21 → 617
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12028.1

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