HSM3 Hsm3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HSM3
Official Full Name: Hsm3p
Primary source: SGD:S000000476
Locus tag: YBR272C
See related: AllianceGenome:SGD:S000000476; FungiDB:YBR272C; VEuPathDB:YBR272C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein folding chaperone. Involved in mismatch repair and proteasome regulatory particle assembly. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HSM3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (746361..747803, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combinations of hsm3 and hsm6 mutations with mutations in other genes of the RAD52 epistatic group did not provide a spontaneous mutation rate decrease.
Title: [Spontaneous mutation rate changes in saccharomyces cerevisiae at combinations of hsm3 and hsm6 mutations with rad52 mutation].
The results made it possible to assume that the hsm3 mutation destabilizes the D-loop, which is a key substrate of both Rad5- and Rad52-dependent postreplicative repair pathways.
Title: [Interaction of the HSM3 gene with genes initiating homologous recombination repair in yeast Saccharomyces cerevisiae].
provide structural and biochemical evidence on how Hsm3/S5b may regulate the 19S RP association to the 20S CP proteasome
Title: Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly.
the structural basis of the molecular functions of Hsm3 for the regulatory particle assembly.
Title: Structural basis for specific recognition of Rpt1p, an ATPase subunit of 26 S proteasome, by proteasome-dedicated chaperone Hsm3p.
Hsm3 protein contains at least two domains; the N-terminal part of the domain is responsible for the proteasome assembly, whereas the C-terminal portion of the protein is responsible for mutagenesis.
Title: [Interaction of gene HSM3 with genes of the epistatic RAD6 group in yeast Saccharomyces cerevisiae].
domain structure of protein Hsm3 and functions of each domain: the N-terminal domain is responsible for binding to mispaired bases, and the C-terminal domain ensures the interaction with other proteins involved in the system of mismatched base correction.
Title: [Genetic analysis of the Hsm3 protein domain structure in yeast Saccharomyces cerevisiae].

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome regulatory particle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Hsm3p

NP_009831.3

Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

746361..747803 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178620.3 → NP_009831.3 TPA: Hsm3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009831.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQR8, P38348

UniProtKB/TrEMBL

A6ZLL1, B5VEL7, C7GMV9, D3UF20, G2W9S6, N1P9N2

Conserved Domains (1) summary

cd12794
Location:9 → 465

Hsm3_like; Hsm3 is a yeast Proteasome chaperone of the 19S regulatory particle and related proteins