SPT8 SAGA complex subunit SPT8 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SPT8
Official Full Name: SAGA complex subunit SPT8
Primary source: SGD:S000004045
Locus tag: YLR055C
See related: AllianceGenome:SGD:S000004045; FungiDB:YLR055C; VEuPathDB:YLR055C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables TBP-class protein binding activity and transcription coregulator activity. Involved in chromatin organization; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription.
Title: Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription.
SAGA-TBP binding involves a network of interactions between subunits Spt3, Spt8, Spt20, and Spt7.
Title: Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
new spt15 mutations partially bypass an spt8 null mutation.
Title: Characterization of new Spt3 and TATA-binding protein mutants of Saccharomyces cerevisiae: Spt3 TBP allele-specific interactions and bypass of Spt8.
Data show that two components of the RNA polymerase II machinery, Med13 (Srb9) and Spt8, are two-hybrid partners of the conserved TFIIS N-terminal domain.
Title: Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

NP_013156.1

Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters

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The following sections contain reference sequences that belong to a specific genome build. Explain