U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    THS1 threonine--tRNA ligase THS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854732, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    THS1
    Official Full Name
    threonine--tRNA ligase THS1
    Primary source
    SGD:S000001340
    Locus tag
    YIL078W
    See related
    AllianceGenome:SGD:S000001340; FungiDB:YIL078W; VEuPathDB:YIL078W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific mRNA binding activity and threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Used to study amino acid metabolic disorder and nonphotosensitive trichothiodystrophy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See THS1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (212499..214703)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene TRAMP complex RNA-binding subunit Neighboring gene Rci37p Neighboring gene coatomer subunit epsilon

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Threonyl-tRNA synthetase from yeast. Discrimination of 19 amino acids in aminoacylation of tRNA(Thr)-C-C-A and tRNA(Thr)-C-C-A(2'NH2). Freist W, et al. Eur J Biochem, 1994 Mar 15. PMID 8143729
    2. Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote. Zhou XL, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23093606, Free PMC Article
    3. Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog. Ruan ZR, et al. J Biol Chem, 2015 Jan 16. PMID 25416776, Free PMC Article
    4. Cloning and characterization of the gene for the yeast cytoplasmic threonyl-tRNA synthetase. Pape LK, et al. Nucleic Acids Res, 1985 Sep 11. PMID 2995918, Free PMC Article
    5. The Cdc48-20S proteasome degrades a class of endogenous proteins in a ubiquitin-independent manner. Islam MT, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954512

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of critical residues in ThrS based on lethal mutations in yeast
      Title: Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in threonyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    threonine--tRNA ligase THS1
    NP_116578.3
    • Threonyl-tRNA synthetase involved in tRNA aminoacylation; mRNA binding protein that preferentially binds to the mRNA of RNAPI subunits and DNA binding proteins; binds to an anticodon stem loop-like structure in RPC10 and impacts its translation; cytoplasmic protein; human homolog TARS can complement a yeast null mutant

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      212499..214703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179428.3 → NP_116578.3  TPA: threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116578.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK6, P04801
      UniProtKB/TrEMBL
      A6ZVJ5
      Conserved Domains (1) summary
      PLN02908
      Location:46 → 728
      PLN02908; threonyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04801.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools