UBA3 NEDD8-activating protein UBA3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UBA3
Official Full Name: NEDD8-activating protein UBA3
Primary source: SGD:S000006270
Locus tag: YPR066W
See related: AllianceGenome:SGD:S000006270; FungiDB:YPR066W; VEuPathDB:YPR066W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NEDD8 activating enzyme activity. Involved in protein neddylation. Located in cytoplasm. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See UBA3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (681213..682112)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NEDD8 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables NEDD8 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NEDD8-activating protein UBA3

NP_015391.1

EC 6.2.1.64

Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

681213..682112

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184163.1 → NP_015391.1 TPA: NEDD8-activating protein UBA3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015391.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W470, E9P8X1, Q99344

UniProtKB/TrEMBL

B3LLB9, C7GY50, C8ZJ91, N1NW24

Conserved Domains (1) summary

cd01488
Location:4 → 294

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...