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    VMA22 Vma22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VMA22
    Official Full Name
    Vma22p
    Primary source
    SGD:S000001102
    Locus tag
    YHR060W
    See related
    AllianceGenome:SGD:S000001102; FungiDB:YHR060W; VEuPathDB:YHR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CEV1; VPH6
    Summary
    Enables unfolded protein binding activity. Involved in vacuolar acidification and vacuolar proton-transporting V-type ATPase complex assembly. Located in nucleus. Part of Vma12-Vma22 assembly complex. Used to study congenital disorder of glycosylation type IIo. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VMA22 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (220725..221270)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mediator complex subunit MED6 Neighboring gene mitochondrial 37S ribosomal protein FYV4 Neighboring gene Gic1p Neighboring gene RNA-binding RNA processing protein RPP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes required for vacuolar acidity in Saccharomyces cerevisiae. Preston RA, et al. Genetics, 1992 Jul. PMID 1628805, Free PMC Article
    2. vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. Hemenway CS, et al. Genetics, 1995 Nov. PMID 8582630, Free PMC Article
    3. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. Hill KJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673216
    4. Assembly of the yeast vacuolar proton-translocating ATPase. Graham LA, et al. J Bioenerg Biomembr, 1999 Feb. PMID 10340847
    5. Assembly of the yeast vacuolar H+-ATPase occurs in the endoplasmic reticulum and requires a Vma12p/Vma22p assembly complex. Graham LA, et al. J Cell Biol, 1998 Jul 13. PMID 9660861, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Vma12-Vma22 assembly complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Vma12-Vma22 assembly complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Vma22p
    NP_011927.1
    • Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      220725..221270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179190.1 → NP_011927.1  TPA: Vma22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL09, P38784
      UniProtKB/TrEMBL
      A6ZSW6, B3LSH9, B5VJY7, C7GTX3, C8Z9J7, G2WFD2, N1P4I6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38784.1

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