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    SWC4 Swc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852885, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWC4
    Official Full Name
    Swc4p
    Primary source
    SGD:S000003234
    Locus tag
    YGR002C
    See related
    AllianceGenome:SGD:S000003234; FungiDB:YGR002C; VEuPathDB:YGR002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EAF2; GOD1
    Summary
    Predicted to enable transcription corepressor activity. Involved in DNA repair; chromatin remodeling; and chromosome organization. Located in nucleus. Part of NuA4 histone acetyltransferase complex and Swr1 complex. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWC4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (498476..499906, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Neighboring gene protein-lysine N-methyltransferase Neighboring gene cullin CUL3 Neighboring gene peroxisome biogenesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Bittner CB, et al. Eukaryot Cell, 2004 Aug. PMID 15302830, Free PMC Article
    2. The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. Eisen A, et al. J Biol Chem, 2001 Feb 2. PMID 11036083
    3. The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part. Miciałkiewicz A, et al. Acta Biochim Pol, 2008. PMID 18726008
    4. Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Boudreault AA, et al. Genes Dev, 2003 Jun 1. PMID 12782659, Free PMC Article
    5. Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. Pan Y, et al. DNA Repair (Amst), 2023 Jul. PMID 37230009

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability.
      Title: Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability.
    2. Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
      Title: Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
    3. N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site.
      Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
    4. Using random mutagenesis we isolated a collection of swc4 mutants and showed that the essential function of Swc4p resides in its N-terminal part, within the first 269 amino acids of the 476-amino acid-long protein.
      Title: The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part.
    5. Results suggest that Yaf9p and Swc4p form a protein pair that has a role in chromatin modification with possible implications also for the function of their mammalian counterparts.
      Title: Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Swc4p
    NP_011516.1
    • Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; associates with and protects nucleosome-free regions of the genome including rDNA, tDNA and telomeric loci, contributing to genome integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      498476..499906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181131.1 → NP_011516.1  TPA: Swc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUD9, P53201
      UniProtKB/TrEMBL
      G2WE95, N1P9T6
      Conserved Domains (1) summary
      pfam16282
      Location:109 → 213
      SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53201.1

    Gene LinkOut

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