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    RSC30 Rsc30p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSC30
    Official Full Name
    Rsc30p
    Primary source
    SGD:S000001098
    Locus tag
    YHR056C
    See related
    AllianceGenome:SGD:S000001098; FungiDB:YHR056C; VEuPathDB:YHR056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including double-strand break repair via nonhomologous end joining; nucleosome disassembly; and transcription elongation by RNA polymerase II. Part of RSC-type complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSC30 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (215183..217834, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1-2 Neighboring gene peptidylprolyl isomerase CPR2 Neighboring gene mediator complex subunit MED6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Echtenkamp FJ, et al. Mol Cell, 2016 Dec 1. PMID 27818141, Free PMC Article
    2. Hal2p functions in Bdf1p-involved salt stress response in Saccharomyces cerevisiae. Chen L, et al. PLoS One, 2013. PMID 23614021, Free PMC Article
    3. Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast. Thierry A, et al. G3 (Bethesda), 2016 May 3. PMID 26945028, Free PMC Article
    4. Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Lorch Y, et al. Cell, 1998 Jul 10. PMID 9674424
    5. RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Oum JH, et al. Mol Cell Biol, 2011 Oct. PMID 21807899, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of Rsc8 and Rsc30, subunits of the Saccharomyces cerevisiae chromatin remodeling complex RSC, as novel NHEJ factors
      Title: The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc30p
    NP_011923.2
    • Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      215183..217834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179186.2 → NP_011923.2  TPA: Rsc30p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011923.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL05, P38781
      UniProtKB/TrEMBL
      C8Z9J3
      Conserved Domains (1) summary
      smart00066
      Location:9 → 47
      GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38781.2

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