U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Itpr1 inositol 1,4,5-trisphosphate receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16438, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itpr1provided by MGI
    Official Full Name
    inositol 1,4,5-trisphosphate receptor 1provided by MGI
    Primary source
    MGI:MGI:96623
    See related
    Ensembl:ENSMUSG00000030102 AllianceGenome:MGI:96623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    opt; Ip3r; P400; Pcp1; wblo; IP3R1; Pcp-1; D6Pas2; IP3R 1; InsP3R; Itpr-1; Gm10429; insP3R1
    Summary
    Enables several functions, including inositol 1,4,5 trisphosphate binding activity; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; and protein homodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of insulin secretion; and protein homotetramerization. Acts upstream of or within several processes, including calcium ion transport; endoplasmic reticulum calcium ion homeostasis; and voluntary musculoskeletal movement. Located in endoplasmic reticulum; nucleus; and postsynaptic density. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 104.2), cortex adult (RPKM 29.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itpr1 in Genome Data Viewer
    Location:
    6 E1- E2; 6 49.74 cM
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (108190044..108528077)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108213083..108551116)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 12 Neighboring gene sulfatase modifying factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6464 Neighboring gene STARR-positive B cell enhancer ABC_E6465 Neighboring gene STARR-positive B cell enhancer ABC_E2199 Neighboring gene predicted gene, 38872 Neighboring gene STARR-positive B cell enhancer mm9_chr6:108228936-108229237 Neighboring gene STARR-positive B cell enhancer ABC_E8120 Neighboring gene STARR-positive B cell enhancer ABC_E3666 Neighboring gene STARR-positive B cell enhancer ABC_E10398 Neighboring gene STARR-seq mESC enhancer starr_16959 Neighboring gene predicted gene, 35165 Neighboring gene microRNA 7661 Neighboring gene STARR-positive B cell enhancer mm9_chr6:108499461-108499762 Neighboring gene STARR-positive B cell enhancer ABC_E4852 Neighboring gene STARR-seq mESC enhancer starr_16963 Neighboring gene predicted gene, 44040 Neighboring gene RIKEN cDNA 0610040F04 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:108580835-108581135 Neighboring gene basic helix-loop-helix family, member e40

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels EXP
    Inferred from Experiment
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables intracellularly gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ligand-gated ion channel signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ligand-gated ion channel signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in single fertilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within voluntary musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in platelet dense granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in platelet dense granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet dense tubular network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in platelet dense tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in smooth endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; inositol 1,4,5-trisphosphate receptor type 1
    Names
    IP3 receptor
    InsP>3<R type I
    Purkinje cell protein 1
    inositol 1,4,5 trisphosphate receptor
    inositol 1,4,5-trisphosphate-binding protein P400
    opisthotonus
    protein PCD-6
    type 1 InsP3 receptor
    type 1 inositol 1,4,5-trisphosphate receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010585.5NP_034715.3  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

      See identical proteins and their annotated locations for NP_034715.3

      Status: VALIDATED

      Source sequence(s)
      AC156506, AK044776, AK047719, AK049015, AK137477, BU705754, CB521690, CF168791, CF539692, CF744794, CJ236273, CK636937, CN459019, CN692248, DN176734, DV652411, M21530
      Consensus CDS
      CCDS51869.1
      UniProtKB/Swiss-Prot
      P11881, P20943, Q99LG5
      Related
      ENSMUSP00000032192.7, ENSMUST00000032192.9
      Conserved Domains (6) summary
      smart00472
      Location:231287
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam00520
      Location:23412600
      Ion_trans; Ion transport protein
      pfam01365
      Location:476665
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19642069
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      108190044..108528077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505623.1XP_006505686.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X1

      Conserved Domains (5) summary
      pfam00520
      Location:23222609
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19732078
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    2. XM_017321407.1XP_017176896.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X2

      Conserved Domains (5) summary
      pfam00520
      Location:23212608
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19722077
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    3. XM_006505627.1XP_006505690.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X6

      Conserved Domains (5) summary
      pfam00520
      Location:23052592
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19562061
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    4. XM_006505624.1XP_006505687.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X3

      Conserved Domains (5) summary
      pfam00520
      Location:23112598
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19622067
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    5. XM_006505625.1XP_006505688.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X4

      Conserved Domains (5) summary
      pfam00520
      Location:23102597
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19612066
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    6. XM_006505632.1XP_006505695.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X11

      Conserved Domains (5) summary
      pfam00520
      Location:22942581
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19452050
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    7. XM_006505628.1XP_006505691.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X7

      Conserved Domains (5) summary
      pfam00520
      Location:22992586
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19502055
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    8. XM_006505629.1XP_006505692.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X8

      Conserved Domains (5) summary
      pfam00520
      Location:22982585
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19492054
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    9. XM_006505633.1XP_006505696.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X12

      Conserved Domains (5) summary
      pfam00520
      Location:22822569
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19332038
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    10. XM_017321408.1XP_017176897.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X15

      UniProtKB/Swiss-Prot
      P11881
      Related
      ENSMUSP00000144880.2, ENSMUST00000203615.3
      Conserved Domains (5) summary
      pfam00520
      Location:23122599
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19632068
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    11. XM_006505636.1XP_006505699.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X18

      UniProtKB/Swiss-Prot
      P11881
      Conserved Domains (5) summary
      pfam00520
      Location:22732560
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19242029
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    12. XM_006505626.1XP_006505689.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X5

      Conserved Domains (5) summary
      pfam00520
      Location:23072594
      Ion_trans; Ion transport protein
      pfam01365
      Location:459655
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19582063
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    13. XM_017321409.1XP_017176898.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X16

      Conserved Domains (5) summary
      pfam00520
      Location:23062593
      Ion_trans; Ion transport protein
      pfam01365
      Location:459655
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19572062
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    14. XM_006505630.1XP_006505693.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X9

      UniProtKB/Swiss-Prot
      P11881
      Conserved Domains (5) summary
      pfam00520
      Location:22982585
      Ion_trans; Ion transport protein
      pfam01365
      Location:459655
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19492054
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    15. XM_017321410.1XP_017176899.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X17

      UniProtKB/Swiss-Prot
      P11881
      Conserved Domains (5) summary
      pfam00520
      Location:22972584
      Ion_trans; Ion transport protein
      pfam01365
      Location:459655
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19482053
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    16. XM_006505637.1XP_006505700.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X19

      UniProtKB/Swiss-Prot
      P11881
      Conserved Domains (5) summary
      pfam00520
      Location:22582545
      Ion_trans; Ion transport protein
      pfam01365
      Location:459655
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232418
      MIR; MIR domain
      pfam08454
      Location:19092014
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    17. XM_006505631.3XP_006505694.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X10

      Conserved Domains (5) summary
      pfam00520
      Location:23222609
      Ion_trans; Ion transport protein
      pfam01365
      Location:474670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232433
      MIR; MIR domain
      pfam08454
      Location:19732078
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4225
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    18. XM_036165883.1XP_036021776.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X14

    19. XM_030255199.1XP_030111059.1  inositol 1,4,5-trisphosphate receptor type 1 isoform X13

      Conserved Domains (5) summary
      pfam00520
      Location:22602547
      Ion_trans; Ion transport protein
      pfam01365
      Location:412608
      RYDR_ITPR; RIH domain
      pfam02815
      Location:170371
      MIR; MIR domain
      pfam08454
      Location:19112016
      RIH_assoc; RyR and IP3R Homology associated
      cl19745
      Location:1163
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor