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    Sntg2 syntrophin, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 268534, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sntg2provided by MGI
    Official Full Name
    syntrophin, gamma 2provided by MGI
    Primary source
    MGI:MGI:1919541
    See related
    Ensembl:ENSMUSG00000020672 AllianceGenome:MGI:1919541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syn5; G2syn; 9530013L23; 2210008K22Rik
    Summary
    Predicted to enable PDZ domain binding activity and neuroligin family protein binding activity. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Is expressed in gut and urinary system. Orthologous to human SNTG2 (syntrophin gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 13.2), colon adult (RPKM 3.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Sntg2 in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30224481..30423424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30174482..30373392, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084 Neighboring gene RIKEN cDNA 2310016D03 gene Neighboring gene receptor-like tyrosine kinase, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuroligin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuroligin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gamma-2-syntrophin
    Names
    syntrophin-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324519.1NP_001311448.1  gamma-2-syntrophin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157276, AC159628
      UniProtKB/TrEMBL
      Q8BZG8
      Conserved Domains (1) summary
      cd00992
      Location:1894
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001324520.1NP_001311449.1  gamma-2-syntrophin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157276, AC159628, AK008673, AK087560, BY098098
      UniProtKB/TrEMBL
      Q8BZG8
    3. NM_001324521.1NP_001311450.1  gamma-2-syntrophin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159628, AK087560, BC058204, BY098098
    4. NM_172951.3NP_766539.2  gamma-2-syntrophin isoform 1

      See identical proteins and their annotated locations for NP_766539.2

      Status: VALIDATED

      Source sequence(s)
      AK035310, AK087560, BC138956, BY098098
      Consensus CDS
      CCDS25858.1
      UniProtKB/Swiss-Prot
      B2RSQ0, Q925E0
      UniProtKB/TrEMBL
      Q8BZG8
      Related
      ENSMUSP00000021004.8, ENSMUST00000021004.14
      Conserved Domains (1) summary
      cd00992
      Location:72153
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_136915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159628, AK087560, BY098098
      Related
      ENSMUST00000142046.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30224481..30423424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315072.2XP_017170561.1  gamma-2-syntrophin isoform X2

      Conserved Domains (1) summary
      cd00992
      Location:1894
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_006515108.2XP_006515171.1  gamma-2-syntrophin isoform X1

      UniProtKB/TrEMBL
      Q8BZG8
      Conserved Domains (1) summary
      cd00992
      Location:72153
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_011243873.1XP_011242175.1  gamma-2-syntrophin isoform X3

    RNA

    1. XR_872414.2 RNA Sequence

      Related
      ENSMUST00000133324.8
    2. XR_003950053.2 RNA Sequence