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    Arid5b AT-rich interaction domain 5B [ Mus musculus (house mouse) ]

    Gene ID: 71371, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arid5bprovided by MGI
    Official Full Name
    AT-rich interaction domain 5Bprovided by MGI
    Primary source
    MGI:MGI:2175912
    See related
    Ensembl:ENSMUSG00000019947 AllianceGenome:MGI:2175912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrf2; Desrt; Mrf2beta; Mrf2alpha; 4930580B11; 5430435G07Rik
    Summary
    Predicted to enable transcription cis-regulatory region binding activity and transcription coactivator activity. Involved in adipose tissue development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; face morphogenesis; and gonad development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.8), bladder adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arid5b in Genome Data Viewer
    Location:
    10 B5.1- B5.2; 10 35.14 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67928353..68114596, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (68092523..68279355, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930521O17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5144 Neighboring gene rhotekin 2 Neighboring gene STARR-seq mESC enhancer starr_27014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:67544592-67544803 Neighboring gene STARR-seq mESC enhancer starr_27016 Neighboring gene STARR-seq mESC enhancer starr_27019 Neighboring gene STARR-seq mESC enhancer starr_27023 Neighboring gene STARR-positive B cell enhancer ABC_E9344 Neighboring gene predicted gene, 51770 Neighboring gene STARR-seq mESC enhancer starr_27025 Neighboring gene STARR-seq mESC enhancer starr_27026 Neighboring gene STARR-positive B cell enhancer ABC_E8342 Neighboring gene STARR-positive B cell enhancer ABC_E3891 Neighboring gene STARR-positive B cell enhancer ABC_E5145 Neighboring gene STARR-seq mESC enhancer starr_27031 Neighboring gene STARR-seq mESC enhancer starr_27032 Neighboring gene STARR-seq mESC enhancer starr_27034 Neighboring gene STARR-positive B cell enhancer ABC_E10619 Neighboring gene STARR-positive B cell enhancer ABC_E8343 Neighboring gene STARR-positive B cell enhancer ABC_E10620 Neighboring gene STARR-seq mESC enhancer starr_27036 Neighboring gene STARR-seq mESC enhancer starr_27037 Neighboring gene STARR-seq mESC enhancer starr_27038 Neighboring gene RIKEN cDNA 4930545H06 gene Neighboring gene predicted gene, 32748

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AT-rich interactive domain-containing protein 5B
    Names
    ARID class DNA binding protein
    ARID domain-containing protein 5B
    AT rich interactive domain 5B (MRF1-like)
    AT rich interactive domain 5B (Mrf1 like)
    MRF-2
    developmentally and sexually retarded with transient immune abnormalities protein
    modulator recognition factor 2
    modulator recognition factor protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023598.2NP_076087.2  AT-rich interactive domain-containing protein 5B

      See identical proteins and their annotated locations for NP_076087.2

      Status: VALIDATED

      Source sequence(s)
      AK029818, AK034633, BY717211, BY720203, CD543091, CN665657
      Consensus CDS
      CCDS35929.1
      UniProtKB/Swiss-Prot
      E9Q523, Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4
      Related
      ENSMUSP00000151227.2, ENSMUST00000219238.2
      Conserved Domains (2) summary
      PTZ00121
      Location:411536
      PTZ00121; MAEBL; Provisional
      cd16885
      Location:321415
      ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      67928353..68114596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245282.2XP_030101142.1  AT-rich interactive domain-containing protein 5B isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:222347
      PTZ00121; MAEBL; Provisional
      cd16885
      Location:132226
      ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
    2. XM_006514129.4XP_006514192.1  AT-rich interactive domain-containing protein 5B isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:437562
      PTZ00121; MAEBL; Provisional
      cd16885
      Location:347441
      ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
    3. XM_006514132.2XP_006514195.1  AT-rich interactive domain-containing protein 5B isoform X3

      See identical proteins and their annotated locations for XP_006514195.1

      Conserved Domains (2) summary
      PTZ00121
      Location:222347
      PTZ00121; MAEBL; Provisional
      cd16885
      Location:132226
      ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
    4. XM_006514131.4XP_006514194.1  AT-rich interactive domain-containing protein 5B isoform X2

      Related
      ENSMUSP00000151665.2, ENSMUST00000218532.2
      Conserved Domains (2) summary
      PTZ00121
      Location:225350
      PTZ00121; MAEBL; Provisional
      cd16885
      Location:135229
      ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
    5. XM_036156016.1XP_036011909.1  AT-rich interactive domain-containing protein 5B isoform X4

      Conserved Domains (2) summary
      PTZ00121
      Location:79204
      PTZ00121; MAEBL; Provisional
      cl28902
      Location:183
      ARID; ARID/BRIGHT DNA binding domain family