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    Ptcra pre T cell antigen receptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 19208, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptcraprovided by MGI
    Official Full Name
    pre T cell antigen receptor alphaprovided by MGI
    Primary source
    MGI:MGI:104857
    See related
    Ensembl:ENSMUSG00000036858 AllianceGenome:MGI:104857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pTa; gp33; pT[a]; pTalpha; pT-alpha; pT-alpha-TCR
    Summary
    Acts upstream of or within negative regulation of thymocyte apoptotic process. Predicted to be located in plasma membrane. Is expressed in thymus and thymus primordium. Orthologous to human PTCRA (pre T cell antigen receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward thymus adult (RPKM 45.7) See more
    Orthologs
    human all
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    Genomic context

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    See Ptcra in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47066589..47074659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46755663..46763712, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glycine N-methyltransferase Neighboring gene canopy FGF signaling regulator 3 Neighboring gene STARR-positive B cell enhancer ABC_E2490 Neighboring gene STARR-positive B cell enhancer ABC_E3204 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46900557-46900758 Neighboring gene peroxisomal biogenesis factor 39 Neighboring gene ribosomal protein L7-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7539

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants. Materna M, et al. Science, 2024 Mar. PMID 38422122, Free PMC Article
    2. The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Balciunaite G, et al. Eur J Immunol, 2005 Apr. PMID 15770699
    3. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. Garbe AI, et al. J Exp Med, 2006 Jun 12. PMID 16754723, Free PMC Article
    4. Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse. Bosco N, et al. J Immunol, 2006 Oct 15. PMID 17015684
    5. Molecular mechanisms of pre-T cell receptor-induced survival. Murga C, et al. J Biol Chem, 2002 Oct 18. PMID 12114514

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pre-TCR expression is not essential for thymic differentiation to DP cells or for V-DJbeta suppression
      Title: The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
    2. expression is up-regulated in regulatory T cells
      Title: Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.
    3. pTalpha plays a role in protecting developing thymocytes from DNA damage in mice
      Title: Molecular mechanisms of pre-T cell receptor-induced survival.
    4. the dosage of E2A, HEB, and SCL determines pT alpha gene expression in immature T cells
      Title: Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
    5. when in competition with pTalpha, TCRalpha induced defective proliferation, survival, and differentiation of alphabeta T lymphocyte precursors
      Title: Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.
    6. The cytoplasmic tail of pTalpha plays a critical role in T lymphocyte development.
      Title: A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.
    7. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
      Title: Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of thymocyte apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    pre T-cell antigen receptor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011195.3 → NP_035325.2  pre T-cell antigen receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      CT030702
      Consensus CDS
      CCDS28840.1
      UniProtKB/Swiss-Prot
      P0C6B2
      Related
      ENSMUSP00000035683.10, ENSMUST00000041012.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47066589..47074659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6B2.1 GenPept UniProtKB/Swiss-Prot:P0C6B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials