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    Acp1 acid phosphatase 1, soluble [ Mus musculus (house mouse) ]

    Gene ID: 11431, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acp1provided by MGI
    Official Full Name
    acid phosphatase 1, solubleprovided by MGI
    Primary source
    MGI:MGI:87881
    See related
    Ensembl:ENSMUSG00000044573 AllianceGenome:MGI:87881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acp-1; Lmptp; LMW-PTP; 4632432E04Rik
    Summary
    Enables acid phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytosol and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acp1 in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30943325..30961616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30893326..30911619, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene ALK and LTK ligand 2 Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103115, MGC132904

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    low molecular weight phosphotyrosine protein phosphatase
    Names
    LMW-PTPase
    low molecular weight cytosolic acid phosphatase
    NP_001103709.1
    NP_067305.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110239.1NP_001103709.1  low molecular weight phosphotyrosine protein phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001103709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2).
      Source sequence(s)
      AC160932, AK014603, AK152429
      Consensus CDS
      CCDS49045.1
      UniProtKB/TrEMBL
      Q561M1
      Related
      ENSMUSP00000073686.6, ENSMUST00000074038.7
      Conserved Domains (1) summary
      cd16343
      Location:7155
      LMWPTP; Low molecular weight protein tyrosine phosphatase
    2. NM_021330.4NP_067305.2  low molecular weight phosphotyrosine protein phosphatase isoform 2

      See identical proteins and their annotated locations for NP_067305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1.
      Source sequence(s)
      AC160932, AK082955
      Consensus CDS
      CCDS36427.1
      UniProtKB/Swiss-Prot
      O88739, O88740, Q9D358, Q9QWF5
      UniProtKB/TrEMBL
      Q4VAI2
      Related
      ENSMUSP00000106509.4, ENSMUST00000062740.15
      Conserved Domains (1) summary
      cd00115
      Location:7155
      LMWPc; Low molecular weight phosphatase family;

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30943325..30961616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_381176.5 RNA Sequence