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    Etv6 ets variant 6 [ Mus musculus (house mouse) ]

    Gene ID: 14011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Etv6provided by MGI
    Official Full Name
    ets variant 6provided by MGI
    Primary source
    MGI:MGI:109336
    See related
    Ensembl:ENSMUSG00000030199 AllianceGenome:MGI:109336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tel
    Summary
    This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in ovary adult (RPKM 13.6), bladder adult (RPKM 11.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Etv6 in Genome Data Viewer
    Location:
    6 G1; 6 64.58 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134012663..134247121)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134035700..134270158)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:133826058-133826359 Neighboring gene kidney androgen regulated protein Neighboring gene STARR-positive B cell enhancer ABC_E8142 Neighboring gene STARR-seq mESC enhancer starr_17533 Neighboring gene STARR-seq mESC enhancer starr_17535 Neighboring gene predicted gene 8956 Neighboring gene STARR-positive B cell enhancer ABC_E3686 Neighboring gene STARR-positive B cell enhancer ABC_E8143 Neighboring gene STARR-positive B cell enhancer ABC_E4873 Neighboring gene predicted gene, 46978 Neighboring gene predicted gene, 52920 Neighboring gene STARR-positive B cell enhancer ABC_E3687 Neighboring gene STARR-positive B cell enhancer ABC_E9281 Neighboring gene RIKEN cDNA 1700051K13 gene Neighboring gene STARR-seq mESC enhancer starr_17540 Neighboring gene predicted gene, 38908 Neighboring gene predicted gene 17089 Neighboring gene RIKEN cDNA 4933406J09 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134288078-134288378 Neighboring gene STARR-seq mESC enhancer starr_17542 Neighboring gene STARR-positive B cell enhancer ABC_E10413 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134339435-134339735 Neighboring gene STARR-seq mESC enhancer starr_17545 Neighboring gene BCL2 like 14 Neighboring gene low density lipoprotein receptor-related protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcription factor ETV6
    Names
    ETS-related protein Tel1
    ets variant gene 6 (TEL oncogene)
    translocation-ets-leukemia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303102.1NP_001290031.1  transcription factor ETV6 isoform 2

      See identical proteins and their annotated locations for NP_001290031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068908, AC113600, AC145116
      UniProtKB/TrEMBL
      Q3U037, Q80WR3
      Related
      ENSMUSP00000107594.2, ENSMUST00000111963.8
      Conserved Domains (3) summary
      cd08535
      Location:1481
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:291377
      ETS; erythroblast transformation specific domain
      pfam09770
      Location:89227
      PAT1; Topoisomerase II-associated protein PAT1
    2. NM_007961.4NP_031987.3  transcription factor ETV6 isoform 1

      See identical proteins and their annotated locations for NP_031987.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068908, AC113600, AC145116
      Consensus CDS
      CCDS39677.1
      UniProtKB/Swiss-Prot
      P97360
      UniProtKB/TrEMBL
      Q8CBV1
      Related
      ENSMUSP00000079818.7, ENSMUST00000081028.13
      Conserved Domains (2) summary
      cd08535
      Location:57124
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:334420
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134012663..134247121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241206.4XP_011239508.1  transcription factor ETV6 isoform X1

      See identical proteins and their annotated locations for XP_011239508.1

      UniProtKB/TrEMBL
      Q3U037, Q80WR3
      Conserved Domains (3) summary
      cd08535
      Location:1481
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:291377
      ETS; erythroblast transformation specific domain
      pfam09770
      Location:89227
      PAT1; Topoisomerase II-associated protein PAT1
    2. XM_011241207.4XP_011239509.1  transcription factor ETV6 isoform X1

      See identical proteins and their annotated locations for XP_011239509.1

      UniProtKB/TrEMBL
      Q3U037, Q80WR3
      Conserved Domains (3) summary
      cd08535
      Location:1481
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:291377
      ETS; erythroblast transformation specific domain
      pfam09770
      Location:89227
      PAT1; Topoisomerase II-associated protein PAT1
    3. XM_011241208.4XP_011239510.1  transcription factor ETV6 isoform X1

      See identical proteins and their annotated locations for XP_011239510.1

      UniProtKB/TrEMBL
      Q3U037, Q80WR3
      Conserved Domains (3) summary
      cd08535
      Location:1481
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:291377
      ETS; erythroblast transformation specific domain
      pfam09770
      Location:89227
      PAT1; Topoisomerase II-associated protein PAT1