Nmnat3 nicotinamide nucleotide adenylyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmnat3provided by MGI
Official Full Name: nicotinamide nucleotide adenylyltransferase 3provided by MGI
Primary source: MGI:MGI:1921330
See related: Ensembl:ENSMUSG00000032456 AllianceGenome:MGI:1921330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PNAT3; 4933408N02Rik
Summary: Enables nicotinamide-nucleotide adenylyltransferase activity. Acts upstream of or within NAD biosynthetic process and response to wounding. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; retina; and urinary system. Orthologous to human NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 10.3), liver E14 (RPKM 9.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.35 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98169487..98302586)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (98287433..98420533)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that Nmnat3 overexpression improves metabolic health and that Nmnat3 is an attractive therapeutic target for metabolic disorders that are caused by aging.
Title: Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.
NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD.
Title: NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Results indicated that Nmnat3 is dispensable in the maintenance of mitochondrial NAD levels, and that other NAD regulatory pathways may exist in mitochondria.
Title: Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo.
Data indicate that nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3)deficiency causes splenomegaly and hemolytic anemia in mice.
Title: Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.
results suggest that axonal protection by NMNAT expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo
Title: Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nicotinamide-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide-nucleotide adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinate-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide adenylyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Names: NMN adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; naMN adenylyltransferase 1; naMN adenylyltransferase 3; nicotinamide mononucleotide adenylyltransferase 3; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 3

NP_001344374.1

EC 2.7.7.1

EC 2.7.7.18

NP_001344375.1

EC 2.7.7.1

EC 2.7.7.18

NP_001344378.1

EC 2.7.7.1

EC 2.7.7.18

NP_001344380.1

EC 2.7.7.1

EC 2.7.7.18

NP_001344381.1

EC 2.7.7.1

EC 2.7.7.18

NP_653116.1

EC 2.7.7.1

EC 2.7.7.18

XP_006511565.1

EC 2.7.7.1

EC 2.7.7.18

XP_006511566.1

EC 2.7.7.1

EC 2.7.7.18

XP_006511567.1

EC 2.7.7.1

EC 2.7.7.18

XP_011241128.1

EC 2.7.7.1

EC 2.7.7.18

XP_011241129.1

EC 2.7.7.1

EC 2.7.7.18

XP_030100520.1

EC 2.7.7.1

EC 2.7.7.18

XP_036011241.1

EC 2.7.7.1

EC 2.7.7.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357445.1 → NP_001344374.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC121597, AC144809, AK041897

Consensus CDS

CCDS90647.1

UniProtKB/TrEMBL

Q3V3C7

Related

ENSMUSP00000108559.2, ENSMUST00000112937.3

Conserved Domains (1) summary

cl00015
Location:1 → 166

nt_trans; nucleotidyl transferase superfamily
NM_001357446.1 → NP_001344375.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC121597, AC144809, BB661406

Conserved Domains (1) summary

cl00015
Location:17 → 122

nt_trans; nucleotidyl transferase superfamily
NM_001357449.1 → NP_001344378.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).

Source sequence(s)

AC121597, AC144809

Consensus CDS

CCDS90646.1

UniProtKB/TrEMBL

Q3V3F1

Conserved Domains (1) summary

cl00015
Location:7 → 121

nt_trans; nucleotidyl transferase superfamily
NM_001357451.1 → NP_001344380.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).

Source sequence(s)

AC121597, AC144809, AK041526

Consensus CDS

CCDS90646.1

UniProtKB/TrEMBL

Q3V3F1

Related

ENSMUSP00000108560.2, ENSMUST00000112938.8

Conserved Domains (1) summary

cl00015
Location:7 → 121

nt_trans; nucleotidyl transferase superfamily
NM_001357452.1 → NP_001344381.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).

Source sequence(s)

AC121597, AC144809, BF472005

Consensus CDS

CCDS90646.1

UniProtKB/TrEMBL

Q3V3F1

Conserved Domains (1) summary

cl00015
Location:7 → 121

nt_trans; nucleotidyl transferase superfamily
NM_144533.3 → NP_653116.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform a

See identical proteins and their annotated locations for NP_653116.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC121597, AC144809

Consensus CDS

CCDS23423.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Related

ENSMUSP00000108557.3, ENSMUST00000112935.8

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

98169487..98302586

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242826.3 → XP_011241128.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_011241128.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
XM_011242827.3 → XP_011241129.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_011241129.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
XM_036155348.1 → XP_036011241.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X2

Conserved Domains (1) summary

cl00015
Location:7 → 121

nt_trans; nucleotidyl transferase superfamily
XM_006511502.4 → XP_006511565.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_006511565.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
XM_006511503.4 → XP_006511566.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_006511566.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
XM_006511504.4 → XP_006511567.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_006511567.1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
XM_030244660.2 → XP_030100520.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

UniProtKB/Swiss-Prot

Q58E37, Q99JR6

Conserved Domains (1) summary

cd09286
Location:7 → 232

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic