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    Rab7b RAB7B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 226421, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab7bprovided by MGI
    Official Full Name
    RAB7B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2442295
    See related
    Ensembl:ENSMUSG00000052688 AllianceGenome:MGI:2442295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430435G22Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of toll-like receptor 4 signaling pathway and negative regulation of toll-like receptor 9 signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in late endosome; lysosome; and phagocytic vesicle. Orthologous to human RAB7B (RAB7B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 5.7), mammary gland adult (RPKM 3.8) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab7b in Genome Data Viewer
    Location:
    1 E4; 1 57.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131616412..131646288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131688681..131715443)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133534791-133534974 Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene cathepsin E Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133554451-133554634 Neighboring gene STARR-seq mESC enhancer starr_02223 Neighboring gene predicted gene, 30104 Neighboring gene solute carrier family 26, member 9 Neighboring gene STARR-seq mESC enhancer starr_02224

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in late endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosome to Golgi transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-7b
    NP_001298025.1
    NP_663484.1
    XP_006529491.1
    XP_006529492.1
    XP_006529493.1
    XP_006529494.1
    XP_006529496.1
    XP_036019822.1
    XP_036019826.1
    XP_036019827.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311096.1NP_001298025.1  ras-related protein Rab-7b isoform 2

      See identical proteins and their annotated locations for NP_001298025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK030688, AK036056, AK163610
      Consensus CDS
      CCDS78677.1
      UniProtKB/TrEMBL
      J9UUF7
      Related
      ENSMUSP00000066452.4, ENSMUST00000064664.10
      Conserved Domains (1) summary
      cd00154
      Location:9132
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    2. NM_145509.3NP_663484.1  ras-related protein Rab-7b isoform 1

      See identical proteins and their annotated locations for NP_663484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138277, AK030688, AK163610
      Consensus CDS
      CCDS15272.1
      UniProtKB/Swiss-Prot
      Q0PD09, Q8BJT0, Q8BZB1, Q8VEA8
      Related
      ENSMUSP00000065456.3, ENSMUST00000064679.9
      Conserved Domains (1) summary
      cd00154
      Location:9169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131616412..131646288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163929.1XP_036019822.1  ras-related protein Rab-7b isoform X2

      Conserved Domains (1) summary
      cd00154
      Location:67227
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    2. XM_006529429.4XP_006529492.1  ras-related protein Rab-7b isoform X3

      Conserved Domains (1) summary
      cd00154
      Location:67190
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    3. XM_006529431.4XP_006529494.1  ras-related protein Rab-7b isoform X6

      Conserved Domains (1) summary
      cl38936
      Location:67155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_006529428.5XP_006529491.1  ras-related protein Rab-7b isoform X1

      Conserved Domains (1) summary
      cd00154
      Location:67227
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    5. XM_006529433.4XP_006529496.1  ras-related protein Rab-7b isoform X8

      UniProtKB/TrEMBL
      D3YZQ6
      Conserved Domains (1) summary
      cl38936
      Location:997
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. XM_036163933.1XP_036019826.1  ras-related protein Rab-7b isoform X4

      Conserved Domains (1) summary
      cd00154
      Location:21181
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    7. XM_036163934.1XP_036019827.1  ras-related protein Rab-7b isoform X7

      UniProtKB/TrEMBL
      J9UUF7
      Conserved Domains (1) summary
      cd00154
      Location:9132
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    8. XM_006529430.3XP_006529493.1  ras-related protein Rab-7b isoform X5

      See identical proteins and their annotated locations for XP_006529493.1

      UniProtKB/Swiss-Prot
      Q0PD09, Q8BJT0, Q8BZB1, Q8VEA8
      Conserved Domains (1) summary
      cd00154
      Location:9169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)