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    Fcrl1 Fc receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 229499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fcrl1provided by MGI
    Official Full Name
    Fc receptor-like 1provided by MGI
    Primary source
    MGI:MGI:2442862
    See related
    Ensembl:ENSMUSG00000059994 AllianceGenome:MGI:2442862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bxmh1; Fcrh1; Ifgp1; Bxmas1; Bxmh1b; Fcrh1l; Fcrh1s; A230020G22Rik
    Summary
    Predicted to enable coreceptor activity. Predicted to be involved in B cell activation. Predicted to be located in cell surface. Orthologous to human FCRL1 (Fc receptor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 18.8), mammary gland adult (RPKM 4.3) and 1 other tissue See more
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    Genomic context

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    See Fcrl1 in Genome Data Viewer
    Location:
    3 F1; 3 38.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87283656..87311274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87376353..87403967)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31879 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87127693-87127994 Neighboring gene predicted gene, 31940 Neighboring gene STARR-positive B cell enhancer ABC_E10187 Neighboring gene STARR-positive B cell enhancer ABC_E9215 Neighboring gene CD5 antigen-like Neighboring gene STARR-positive B cell enhancer ABC_E3443 Neighboring gene STARR-seq mESC enhancer starr_08155 Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene Fc receptor-like 5 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Zhao X, et al. Sci Adv, 2019 Jul. PMID 31328160, Free PMC Article
    2. FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. DeLuca JM, et al. J Immunol, 2021 Dec 1. PMID 34697226, Free PMC Article
    3. Differential B cell expression of mouse Fc receptor homologs. Davis RS, et al. Int Immunol, 2004 Sep. PMID 15302849
    4. Species-specific evolution of the FcR family in endothermic vertebrates. Fayngerts SA, et al. Immunogenetics, 2007 Jun. PMID 17356879
    5. New nomenclature for Fc receptor-like molecules. Maltais LJ, et al. Nat Immunol, 2006 May. PMID 16622424

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like protein 1
    Names
    BXMAS1-like protein 1
    BXMAS1-like protein 1b
    IFGP family protein 1
    fc receptor homolog 1
    fcR-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136236.1 → NP_001129708.1  Fc receptor-like protein 1 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and mid coding regions, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK038494, AK041750
      Consensus CDS
      CCDS50942.1
      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      UniProtKB/TrEMBL
      E9Q5S9
      Related
      ENSMUSP00000128235.2, ENSMUST00000167200.7
      Conserved Domains (3) summary
      smart00410
      Location:28 → 98
      IG_like; Immunoglobulin like
      pfam00047
      Location:28 → 104
      ig; Immunoglobulin domain
      pfam13927
      Location:116 → 189
      Ig_3; Immunoglobulin domain

    2. NM_001310545.1 → NP_001297474.1  Fc receptor-like protein 1 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC163618, AK038494, AK041750, BB219508
      Consensus CDS
      CCDS79937.1
      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      UniProtKB/TrEMBL
      A0A0A6YY56
      Related
      ENSMUSP00000142286.2, ENSMUST00000194786.6
      Conserved Domains (3) summary
      smart00410
      Location:28 → 98
      IG_like; Immunoglobulin like
      pfam13927
      Location:116 → 189
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28 → 104
      Ig; Immunoglobulin domain

    3. NM_153090.2 → NP_694730.2  Fc receptor-like protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK038494, AK041750
      Consensus CDS
      CCDS50941.1
      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      UniProtKB/TrEMBL
      E9Q958
      Related
      ENSMUSP00000130936.2, ENSMUST00000163661.8
      Conserved Domains (3) summary
      smart00410
      Location:48 → 118
      IG_like; Immunoglobulin like
      pfam00047
      Location:48 → 124
      ig; Immunoglobulin domain
      pfam13927
      Location:136 → 209
      Ig_3; Immunoglobulin domain

    4. NM_178165.4 → NP_835459.1  Fc receptor-like protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_835459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK038494, AK041750
      Consensus CDS
      CCDS17452.1
      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      UniProtKB/TrEMBL
      A0A0R4J0W8
      Related
      ENSMUSP00000072300.3, ENSMUST00000072480.9
      Conserved Domains (3) summary
      smart00410
      Location:28 → 98
      IG_like; Immunoglobulin like
      pfam13927
      Location:116 → 189
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28 → 104
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87283656..87311274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501337.4 → XP_006501400.1  Fc receptor-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      Conserved Domains (2) summary
      smart00409
      Location:1 → 65
      IG; Immunoglobulin
      pfam13927
      Location:84 → 156
      Ig_3; Immunoglobulin domain

    2. XM_017319541.3 → XP_017175030.1  Fc receptor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      Conserved Domains (2) summary
      smart00409
      Location:28 → 98
      IG; Immunoglobulin
      pfam13927
      Location:117 → 189
      Ig_3; Immunoglobulin domain

    3. XM_030252566.2 → XP_030108426.1  Fc receptor-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
      Conserved Domains (2) summary
      smart00409
      Location:1 → 65
      IG; Immunoglobulin
      pfam13927
      Location:84 → 156
      Ig_3; Immunoglobulin domain

    RNA

    1. XR_001783682.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4Y0.1 GenPept UniProtKB/Swiss-Prot:Q8R4Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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