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    Zfp286 zinc finger protein 286 [ Mus musculus (house mouse) ]

    Gene ID: 192651, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp286provided by MGI
    Official Full Name
    zinc finger protein 286provided by MGI
    Primary source
    MGI:MGI:2384758
    See related
    Ensembl:ENSMUSG00000047342 AllianceGenome:MGI:2384758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to several human genes including ZNF286A (zinc finger protein 286A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 2.6), CNS E18 (RPKM 2.5) and 12 other tissues See more
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    Genomic context

    See Zfp286 in Genome Data Viewer
    Location:
    11 B2; 11 38.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62640003..62680385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62751951..62789506, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA) Neighboring gene WD repeat and SOCS box-containing 2, pseudogene Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Clone Names

    • MGC39058

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364096.1NP_001351025.1  zinc finger protein 286A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627097, BB627774
      Conserved Domains (5) summary
      smart00349
      Location:162
      KRAB; krueppel associated box
      COG5048
      Location:301461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207231
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001364097.1NP_001351026.1  zinc finger protein 286A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627097
      Conserved Domains (5) summary
      smart00349
      Location:162
      KRAB; krueppel associated box
      COG5048
      Location:301461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207231
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001364098.1NP_001351027.1  zinc finger protein 286A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627097
      Consensus CDS
      CCDS88169.1
      UniProtKB/TrEMBL
      Q5SVS7
      Related
      ENSMUSP00000104345.2, ENSMUST00000108705.8
      Conserved Domains (1) summary
      smart00349
      Location:50111
      KRAB; krueppel associated box
    4. NM_001364100.1NP_001351029.1  zinc finger protein 286A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627097, BC038632
      Related
      ENSMUST00000145474.8
      Conserved Domains (1) summary
      smart00349
      Location:50111
      KRAB; krueppel associated box
    5. NM_138949.4NP_620399.3  zinc finger protein 286A isoform 1

      See identical proteins and their annotated locations for NP_620399.3

      Status: VALIDATED

      Source sequence(s)
      AK031547, AL627097, CJ164719
      Consensus CDS
      CCDS24831.1
      UniProtKB/TrEMBL
      Q8C0E6
      Related
      ENSMUSP00000055517.7, ENSMUST00000054654.13
      Conserved Domains (6) summary
      smart00349
      Location:50111
      KRAB; krueppel associated box
      COG5048
      Location:350510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:352374
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:5085
      KRAB; KRAB box
      pfam13465
      Location:422447
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62640003..62680385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245695.2XP_030101555.1  zinc finger protein 286A isoform X7

      UniProtKB/TrEMBL
      A0A140LIZ8
      Related
      ENSMUSP00000147022.2, ENSMUST00000207597.2
      Conserved Domains (1) summary
      smart00349
      Location:50111
      KRAB; krueppel associated box
    2. XM_030245694.2XP_030101554.1  zinc finger protein 286A isoform X6

      Conserved Domains (1) summary
      smart00349
      Location:107168
      KRAB; krueppel associated box
    3. XM_017314347.2XP_017169836.1  zinc finger protein 286A isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:234394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:153175
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:140164
      zf-H2C2_2; Zinc-finger double domain
    4. XM_030245693.1XP_030101553.1  zinc finger protein 286A isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:234394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:153175
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:140164
      zf-H2C2_2; Zinc-finger double domain
    5. XM_011248814.1XP_011247116.1  zinc finger protein 286A isoform X4

      See identical proteins and their annotated locations for XP_011247116.1

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149173
      zf-H2C2_2; Zinc-finger double domain
    6. XM_030245692.2XP_030101552.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149173
      zf-H2C2_2; Zinc-finger double domain
    7. XM_030245691.2XP_030101551.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149173
      zf-H2C2_2; Zinc-finger double domain
    8. XM_030245690.2XP_030101550.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149173
      zf-H2C2_2; Zinc-finger double domain
    9. XM_011248815.3XP_011247117.1  zinc finger protein 286A isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:316476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:348368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:235257
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222246
      zf-H2C2_2; Zinc-finger double domain
    10. XM_011248812.3XP_011247114.1  zinc finger protein 286A isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:162
      KRAB; krueppel associated box
      COG5048
      Location:301461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207231
      zf-H2C2_2; Zinc-finger double domain
    11. XM_036156440.1XP_036012333.1  zinc finger protein 286A isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:340500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:372392
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259281
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:246270
      zf-H2C2_2; Zinc-finger double domain
    12. XM_006532543.3XP_006532606.3  zinc finger protein 286A isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:370530
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:289311
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:276300
      zf-H2C2_2; Zinc-finger double domain
    13. XM_011248811.4XP_011247113.2  zinc finger protein 286A isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:162
      KRAB; krueppel associated box
      COG5048
      Location:301461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207231
      zf-H2C2_2; Zinc-finger double domain