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    Nt5c1b 5'-nucleotidase, cytosolic IB [ Mus musculus (house mouse) ]

    Gene ID: 70881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5c1bprovided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IBprovided by MGI
    Primary source
    MGI:MGI:1918131
    See related
    Ensembl:ENSMUSG00000020622 AllianceGenome:MGI:1918131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIRP; cN1B; CN-IB; 4921514H13Rik
    Summary
    Enables 5'-nucleotidase activity. Involved in AMP catabolic process; allantoin metabolic process; and amide catabolic process. Acts upstream of or within nucleoside metabolic process. Is active in cytosol. Is expressed in several structures, including genitourinary system; gut; and skin. Orthologous to several human genes including NT5C1B (5'-nucleotidase, cytosolic IB). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 189.3) See more
    Orthologs
    human all
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    Genomic context

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    See Nt5c1b in Genome Data Viewer
    Location:
    12 A1.1; 12 5.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (10419971..10440174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (10369971..10390174)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46324 Neighboring gene acetyl-Coenzyme A carboxylase alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5319 Neighboring gene retinol dehydrogenase 14 (all-trans and 9-cis) Neighboring gene predicted gene, 38407 Neighboring gene STARR-seq mESC enhancer starr_31530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon. Homola M, et al. Cell Tissue Res, 2016 Jul. PMID 26917036
    2. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. Sala-Newby GB, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690631
    3. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecto-5'-nucleotidase mRNA levels were found to be diminished in both MT1 and MT1/2 knockout mice.
      Title: Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (3) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleoside metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic 5'-nucleotidase 1B
    Names
    5'nucleotidase
    autoimmune infertility-related protein
    cytosolic 5'-nucleotidase IB
    NP_001297511.1
    NP_001360900.1
    NP_001360901.1
    NP_001360902.1
    NP_001360903.1
    NP_001360904.1
    NP_081864.2
    XP_006515274.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310582.1 → NP_001297511.1  cytosolic 5'-nucleotidase 1B isoform 2

      See identical proteins and their annotated locations for NP_001297511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC157570, BC060976
      Consensus CDS
      CCDS79106.1
      UniProtKB/TrEMBL
      A0A1W2P7S7, Q6P906
      Related
      ENSMUSP00000112694.2, ENSMUST00000118657.8
      Conserved Domains (1) summary
      pfam06189
      Location:280 → 548
      5-nucleotidase; 5'-nucleotidase

    2. NM_001373971.1 → NP_001360900.1  cytosolic 5'-nucleotidase 1B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC157570
      Consensus CDS
      CCDS88310.1
      UniProtKB/TrEMBL
      A0A1W2P6X8
      Related
      ENSMUSP00000151401.2, ENSMUST00000219826.2
      Conserved Domains (1) summary
      pfam06189
      Location:356 → 624
      5-nucleotidase; 5'-nucleotidase

    3. NM_001373972.1 → NP_001360901.1  cytosolic 5'-nucleotidase 1B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Conserved Domains (1) summary
      pfam06189
      Location:354 → 622
      5-nucleotidase; 5'-nucleotidase

    4. NM_001373973.1 → NP_001360902.1  cytosolic 5'-nucleotidase 1B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Consensus CDS
      CCDS88309.1
      UniProtKB/TrEMBL
      A0A1W2P7K9, A0A1W2P7S7
      Related
      ENSMUSP00000151734.2, ENSMUST00000217944.2
      Conserved Domains (1) summary
      pfam06189
      Location:340 → 608
      5-nucleotidase; 5'-nucleotidase

    5. NM_001373974.1 → NP_001360903.1  cytosolic 5'-nucleotidase 1B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Consensus CDS
      CCDS88311.1
      UniProtKB/TrEMBL
      A0A1W2P7E9, A0A1W2P7S7
      Related
      ENSMUSP00000151618.3, ENSMUST00000218339.3
      Conserved Domains (1) summary
      pfam06189
      Location:296 → 564
      5-nucleotidase; 5'-nucleotidase

    6. NM_001373975.1 → NP_001360904.1  cytosolic 5'-nucleotidase 1B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Consensus CDS
      CCDS88312.1
      UniProtKB/TrEMBL
      A0A1W2P7S7, A0A1Y7VK90
      Related
      ENSMUSP00000152838.2, ENSMUST00000223534.2
      Conserved Domains (1) summary
      pfam06189
      Location:282 → 550
      5-nucleotidase; 5'-nucleotidase

    7. NM_027588.3 → NP_081864.2  cytosolic 5'-nucleotidase 1B isoform 1

      See identical proteins and their annotated locations for NP_081864.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK014892, BB573272
      Consensus CDS
      CCDS25810.1
      UniProtKB/Swiss-Prot
      E9QNH2, Q91Y48, Q91YE9
      UniProtKB/TrEMBL
      A0A1W2P7S7
      Related
      ENSMUSP00000002456.9, ENSMUST00000002456.10
      Conserved Domains (1) summary
      pfam06189
      Location:298 → 566
      5-nucleotidase; 5'-nucleotidase

    RNA

    1. NR_164200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000219292.2

    2. NR_164201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000219049.2

    3. NR_164202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000218417.2

    4. NR_164203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000218287.2

    5. NR_164204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000218551.2

    6. NR_164205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000218026.2

    7. NR_164206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570

    8. NR_164207.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157570
      Related
      ENSMUST00000218327.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      10419971..10440174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515211.4 → XP_006515274.1  cytosolic 5'-nucleotidase 1B isoform X1

      UniProtKB/TrEMBL
      A0A1W2P7D6
      Related
      ENSMUSP00000151627.2, ENSMUST00000220257.2
      Conserved Domains (1) summary
      pfam06189
      Location:356 → 376
      5-nucleotidase; 5'-nucleotidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YE9.2 GenPept UniProtKB/Swiss-Prot:Q91YE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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