Myl3 myosin, light polypeptide 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myl3provided by MGI
Official Full Name: myosin, light polypeptide 3provided by MGI
Primary source: MGI:MGI:97268
See related: Ensembl:ENSMUSG00000059741 AllianceGenome:MGI:97268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mylc; VLC1; MLC1s; MLC1v; MLC1SB
Summary: Predicted to enable actin monomer binding activity and cytoskeletal motor activity. Predicted to be involved in several processes, including cardiac muscle contraction; regulation of the force of heart contraction; and ventricular cardiac muscle tissue morphogenesis. Predicted to be located in A band and I band. Predicted to be part of myosin II complex. Is expressed in several structures, including diaphragm; eye; heart; limb segment; and skeletal musculature. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward heart adult (RPKM 3314.7) See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 60.69 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110592746..110598870)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (110763678..110769802)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.
Title: MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit37 (e-PCR), detects polymorphism
- UniSTS:131929

RH138771 (e-PCR)
- UniSTS:220858

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of striated muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in A band	ISO Inferred from Sequence Orthology more info
located_in I band	IEA Inferred from Electronic Annotation more info
located_in I band	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin light chain 3

Names: myosin light chain, alkali, cardiac ventricles; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.