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    Dennd10 DENN domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 67894, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dennd10provided by MGI
    Official Full Name
    DENN domain containing 10provided by MGI
    Primary source
    MGI:MGI:1915144
    See related
    Ensembl:ENSMUSG00000024993 AllianceGenome:MGI:1915144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam45a; 1810055E12Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.5), placenta adult (RPKM 12.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd10 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60800029..60824673)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60811555..60836235)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11044 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene sideroflexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene peroxiredoxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 10
    Names
    family with sequence similarity 45, member A
    protein FAM45A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167829.3 → NP_001161301.1  DENN domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163019
      UniProtKB/Swiss-Prot
      Q9D8N2
      Conserved Domains (1) summary
      pfam09794
      Location:139 → 241
      Avl9; Transport protein Avl9

    2. NM_001347464.2 → NP_001334393.1  DENN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163019
      Consensus CDS
      CCDS84460.1
      UniProtKB/TrEMBL
      Q3TH34
      Conserved Domains (1) summary
      cl40631
      Location:37 → 143
      SPA; Stabilization of polarity axis

    3. NM_001360619.2 → NP_001347548.1  DENN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163019
      Consensus CDS
      CCDS84460.1
      UniProtKB/TrEMBL
      Q3TH34
      Related
      ENSMUSP00000112839.2, ENSMUST00000119633.8
      Conserved Domains (1) summary
      cl40631
      Location:37 → 143
      SPA; Stabilization of polarity axis

    4. NM_001360620.2 → NP_001347549.2  DENN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163019
      UniProtKB/TrEMBL
      Q3TH34
      Conserved Domains (1) summary
      cl40631
      Location:37 → 143
      SPA; Stabilization of polarity axis

    5. NM_026437.5 → NP_080713.2  DENN domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_080713.2

      Status: VALIDATED

      Source sequence(s)
      AC163019
      Consensus CDS
      CCDS29942.1
      UniProtKB/Swiss-Prot
      Q3UL11, Q91WS5, Q9D8N2
      Related
      ENSMUSP00000025957.9, ENSMUST00000025957.9
      Conserved Domains (1) summary
      pfam08616
      Location:158 → 264
      SPA; Stabilization of polarity axis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60800029..60824673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8N2.2 GenPept UniProtKB/Swiss-Prot:Q9D8N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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