Pomc pro-opiomelanocortin-alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pomcprovided by MGI
Official Full Name: pro-opiomelanocortin-alphaprovided by MGI
Primary source: MGI:MGI:97742
See related: Ensembl:ENSMUSG00000020660 AllianceGenome:MGI:97742
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH
Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Biased expression in testis adult (RPKM 4.3), CNS E14 (RPKM 2.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 1.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4004945..4010643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (3954945..3960643)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.
Title: The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.
Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance.
Title: Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance.
Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.
Title: Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.
Protein Tyrosine Phosphatase Receptors N and N2 Control Pituitary Melanotroph Development and POMC Expression.
Title: Protein Tyrosine Phosphatase Receptors N and N2 Control Pituitary Melanotroph Development and POMC Expression.
beta-Endorphin influences sedative and ataxic effects of alcohol.
Title: β-Endorphin influences sedative and ataxic effects of alcohol.
POMC-specific knockdown of MeCP2 leads to adverse phenotypes in mice chronically exposed to high fat diet.
Title: POMC-specific knockdown of MeCP2 leads to adverse phenotypes in mice chronically exposed to high fat diet.
Solar ultraviolet B radiation promotes alpha-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis.
Title: Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis.
Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice.
Title: Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice.
Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits.
Title: Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits.
Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation.
Title: Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation.

Submit: New GeneRIF Correction See all GeneRIFs (180)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130758 (e-PCR)
- UniSTS:214042

Pomc (e-PCR), detects polymorphism
- UniSTS:507166

Pomc1 (e-PCR), detects polymorphism
- UniSTS:498751

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 melanocortin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 3 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 3 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 4 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 4 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular pigmentation	ISO Inferred from Sequence Orthology more info
involved_in cellular pigmentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in generation of precursor metabolites and energy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in modulation of process of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil mediated killing of fungus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxytocin production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of corticosterone secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to melanocyte-stimulating hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pro-opiomelanocortin

Names: adrenal corticotropic hormone; adrenocorticotropic hormone; alpha-melanocyte stimulating hormone; beta-endorphin; corticotropin-like intermediary peptide; corticotropin-lipotropin; melanotropin gamma; met-enkephalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278581.1 → NP_001265510.1 pro-opiomelanocortin preproprotein

See identical proteins and their annotated locations for NP_001265510.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC111092, AW120866, BB022229, BB022936, BB025409, BB026464

Consensus CDS

CCDS25785.1

UniProtKB/Swiss-Prot

P01193, P01200, Q544U4

Conserved Domains (3) summary

pfam00976
Location:186 → 204

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:205 → 232

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:28 → 70

NPP; Pro-opiomelanocortin, N-terminal region
NM_001278582.1 → NP_001265511.1 pro-opiomelanocortin preproprotein

See identical proteins and their annotated locations for NP_001265511.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC111092, AW120866, BB022229, BB022936, BB025409, BB026464

Consensus CDS

CCDS25785.1

UniProtKB/Swiss-Prot

P01193, P01200, Q544U4

Conserved Domains (3) summary

pfam00976
Location:186 → 204

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:205 → 232

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:28 → 70

NPP; Pro-opiomelanocortin, N-terminal region
NM_001278583.1 → NP_001265512.1 pro-opiomelanocortin preproprotein

See identical proteins and their annotated locations for NP_001265512.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC111092, AK030714, BB022936, BB025409, BB026464

Consensus CDS

CCDS25785.1

UniProtKB/Swiss-Prot

P01193, P01200, Q544U4

Related

ENSMUSP00000151504.2, ENSMUST00000219543.2

Conserved Domains (3) summary

pfam00976
Location:186 → 204

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:205 → 232

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:28 → 70

NPP; Pro-opiomelanocortin, N-terminal region
NM_001278584.1 → NP_001265513.1 pro-opiomelanocortin preproprotein

See identical proteins and their annotated locations for NP_001265513.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC111092, AK017581, BB025409, BB026464

Consensus CDS

CCDS25785.1

UniProtKB/Swiss-Prot

P01193, P01200, Q544U4

Related

ENSMUSP00000151367.2, ENSMUST00000218089.2

Conserved Domains (3) summary

pfam00976
Location:186 → 204

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:205 → 232

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:28 → 70

NPP; Pro-opiomelanocortin, N-terminal region
NM_008895.4 → NP_032921.1 pro-opiomelanocortin preproprotein

See identical proteins and their annotated locations for NP_032921.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC111092, AK017492, AK133646, BB025409

Consensus CDS

CCDS25785.1

UniProtKB/Swiss-Prot

P01193, P01200, Q544U4

Related

ENSMUSP00000020990.6, ENSMUST00000020990.7

Conserved Domains (3) summary

pfam00976
Location:186 → 204

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:205 → 232

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:28 → 70

NPP; Pro-opiomelanocortin, N-terminal region