C1qb complement component 1, q subcomponent, beta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1qbprovided by MGI
Official Full Name: complement component 1, q subcomponent, beta polypeptideprovided by MGI
Primary source: MGI:MGI:88224
See related: Ensembl:ENSMUSG00000036905 AllianceGenome:MGI:88224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adia
Summary: Enables identical protein binding activity. Involved in synapse pruning. Acts upstream of or within inner ear development. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 131.9), spleen adult (RPKM 123.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 69.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (136607437..136613511, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136880126..136886200, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mRNA levels of H2-d1 in the prefrontal cortex, hippocampus, and hypothalamus and C1qb in the hippocampus of the DBA/2 J strain were significantly down-regulated as compared to those in the C57BL/6 J strain
Title: Association of brain immune genes with social behavior of inbred mouse strains.
analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages
Title: Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse pruning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of complement component C1 complex	ISO Inferred from Sequence Orthology more info
part_of complement component C1 complex	NAS Non-traceable Author Statement more info	PubMed
part_of complement component C1q complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extrinsic component of postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IGI Inferred from Genetic Interaction more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IGI Inferred from Genetic Interaction more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q subcomponent subunit B

Names: adiponectin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009777.3 → NP_033907.1 complement C1q subcomponent subunit B precursor

See identical proteins and their annotated locations for NP_033907.1

Status: VALIDATED

Source sequence(s)

AL627214

Consensus CDS

CCDS18810.1

UniProtKB/Swiss-Prot

P14106, Q3U793

UniProtKB/TrEMBL

Q3U6I5, Q3US82

Related

ENSMUSP00000040246.9, ENSMUST00000046384.9

Conserved Domains (2) summary

pfam01391
Location:49 → 107

Collagen; Collagen triple helix repeat (20 copies)

cl23878
Location:113 → 250

C1q; C1q domain