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    Plcb1 phospholipase C, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 18795, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plcb1provided by MGI
    Official Full Name
    phospholipase C, beta 1provided by MGI
    Primary source
    MGI:MGI:97613
    See related
    Ensembl:ENSMUSG00000051177 AllianceGenome:MGI:97613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plcb; mKIAA0581; 3110043I21Rik
    Summary
    Enables lamin binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cell cycle process; and regulation of macromolecule biosynthetic process. Located in chromatin; cytoplasm; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 8.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plcb1 in Genome Data Viewer
    Location:
    2 F3; 2 65.66 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (134628084..135317178)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (134786164..135475258)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05771 Neighboring gene predicted gene 14037 Neighboring gene zinc finger, AN1-type domain 1 pseudogene Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05772 Neighboring gene predicted gene, 39941 Neighboring gene STARR-seq mESC enhancer starr_05773 Neighboring gene STARR-seq mESC enhancer starr_05774 Neighboring gene STARR-seq mESC enhancer starr_05775 Neighboring gene RIKEN cDNA 4930545L23 gene Neighboring gene STARR-seq mESC enhancer starr_05777 Neighboring gene STARR-seq mESC enhancer starr_05778 Neighboring gene STARR-seq mESC enhancer starr_05779 Neighboring gene RIKEN cDNA 9630028H03 gene Neighboring gene STARR-seq mESC enhancer starr_05782 Neighboring gene STARR-seq mESC enhancer starr_05783 Neighboring gene predicted gene, 31993

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in activation of meiosis involved in egg activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell adhesion IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cellular response to fluoride IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fluoride ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glyceraldehyde IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glyceraldehyde ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionomycin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionomycin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vasopressin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vasopressin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inositol trisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol trisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-12-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-15-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-15-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ligand-gated ion channel signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in macrophage differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in memory IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of monocyte extravasation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oocyte maturation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in phosphatidylinositol catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of CD24 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of sodium:proton antiporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to monosaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic cytosol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
    Names
    PLC-154
    PLC-beta-1
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-beta-1
    phospholipase C-beta-1a
    NP_001139302.1
    NP_062651.2
    XP_006498993.1
    XP_036015453.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145830.1NP_001139302.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001139302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK143153, AL935278, BC058710
      Consensus CDS
      CCDS50729.1
      UniProtKB/Swiss-Prot
      Q62075, Q6PDH1, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z1B3, Q9Z2T5
      UniProtKB/TrEMBL
      Q2M4J2
      Related
      ENSMUSP00000105743.2, ENSMUST00000110116.8
      Conserved Domains (7) summary
      cd00275
      Location:677796
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316643
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:216784
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:22148
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:903939
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:10031172
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:224314
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    2. NM_019677.2NP_062651.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

      See identical proteins and their annotated locations for NP_062651.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' exon that contains an in-frame stop codon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK143153, AL935278, BC058710, BU846788
      Consensus CDS
      CCDS16787.1
      UniProtKB/TrEMBL
      Q2M4J2
      Related
      ENSMUSP00000118756.3, ENSMUST00000131552.5
      Conserved Domains (7) summary
      cd00275
      Location:677796
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316643
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:216784
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:22148
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:903939
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:10031141
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:224314
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      134628084..135317178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498930.4XP_006498993.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

      UniProtKB/TrEMBL
      Q2M4J2
      Conserved Domains (6) summary
      cd00275
      Location:624743
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:263590
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:595
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16208
      Location:100250
      EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)
      pfam06631
      Location:850886
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:9501119
      PLC-beta_C; PLC-beta C terminal
    2. XM_036159560.1XP_036015453.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

      UniProtKB/TrEMBL
      Q2M4J2
      Conserved Domains (5) summary
      cd00275
      Location:576695
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:215542
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd16208
      Location:52202
      EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)
      pfam08703
      Location:9021071
      PLC-beta_C; PLC-beta C terminal
      cl17171
      Location:147
      PH-like; Pleckstrin homology-like domain