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    Eipr1 EARP complex and GARP complex interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 380752, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eipr1provided by MGI
    Official Full Name
    EARP complex and GARP complex interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1289332
    See related
    Ensembl:ENSMUSG00000036613 AllianceGenome:MGI:1289332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tssc1; D12Ertd604e
    Summary
    Predicted to be involved in several processes, including endocytic recycling; positive regulation of intracellular transport; and regulation of insulin secretion. Predicted to be located in trans-Golgi network. Predicted to be part of EARP complex and GARP complex. Is expressed in hippocampus; liver; neural retina; and olfactory epithelium. Orthologous to human EIPR1 (EARP complex and GARP complex interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.6), CNS E18 (RPKM 12.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eipr1 in Genome Data Viewer
    Location:
    12 A2; 12 11.26 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (28801802..28917493)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (28751802..28867494)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 6937 Neighboring gene trafficking protein particle complex 12 Neighboring gene STARR-seq mESC enhancer starr_31820 Neighboring gene acireductone dioxygenase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9386 Neighboring gene predicted gene, 31269 Neighboring gene STARR-seq mESC enhancer starr_31822 Neighboring gene predicted gene, 46345 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:29519262-29519445 Neighboring gene STARR-seq mESC enhancer starr_31825 Neighboring gene STARR-seq mESC enhancer starr_31826 Neighboring gene predicted gene, 31508 Neighboring gene STARR-seq mESC enhancer starr_31827 Neighboring gene STARR-seq mESC enhancer starr_31828 Neighboring gene predicted gene, 31333 Neighboring gene STARR-seq mESC enhancer starr_31829

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dense core granule transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of EARP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of EARP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of GARP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of GARP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    EARP and GARP complex-interacting protein 1
    Names
    EARP-interacting protein
    Golgi-associated retrograde protein-interacting protein
    endosome-associated recycling protein-interacting protein
    protein TSSC1
    tumor suppressing subtransferable candidate 1
    tumor-suppressing STF cDNA 1 protein
    tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379229.1NP_001366158.1  EARP and GARP complex-interacting protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AC136986, CT010449
      Conserved Domains (2) summary
      sd00039
      Location:3774
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:35273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001379230.2NP_001366159.1  EARP and GARP complex-interacting protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC136986, CT010449
      Conserved Domains (2) summary
      sd00039
      Location:3774
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:35273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001403164.1NP_001390093.1  EARP and GARP complex-interacting protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC136986, CT010449
    4. NM_001403165.1NP_001390094.1  EARP and GARP complex-interacting protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC136986, CT010449
    5. NM_201357.3NP_958745.2  EARP and GARP complex-interacting protein 1 isoform a

      See identical proteins and their annotated locations for NP_958745.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC136986, CT010449
      Consensus CDS
      CCDS25855.1
      UniProtKB/Swiss-Prot
      E9QN80, Q8K0G5
      Related
      ENSMUSP00000152220.2, ENSMUST00000221877.2
      Conserved Domains (3) summary
      COG2319
      Location:39373
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:137174
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:135373
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      28801802..28917493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515121.5XP_006515184.1  EARP and GARP complex-interacting protein 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:108147
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:105356
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_011243879.4XP_011242181.1  EARP and GARP complex-interacting protein 1 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:3877
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:35286
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...