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    Syt10 synaptotagmin X [ Mus musculus (house mouse) ]

    Gene ID: 54526, updated on 9-Dec-2024

    Summary

    Official Symbol
    Syt10provided by MGI
    Official Full Name
    synaptotagmin Xprovided by MGI
    Primary source
    MGI:MGI:1859546
    See related
    Ensembl:ENSMUSG00000063260 AllianceGenome:MGI:1859546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables several functions, including calcium ion binding activity; phospholipid binding activity; and protein dimerization activity. Involved in positive regulation of calcium ion-dependent exocytosis; presynaptic dense core vesicle exocytosis; and sensory perception of smell. Located in exocytic vesicle. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; ear; and skeleton. Orthologous to human SYT10 (synaptotagmin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.7), cortex adult (RPKM 0.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Syt10 in Genome Data Viewer
    Location:
    15 E3; 15 44.96 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89657221..89726181, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89773714..89841980, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39471 Neighboring gene NMD3 homolog pseudogene Neighboring gene predicted gene, 19378 Neighboring gene STARR-seq mESC enhancer starr_39472 Neighboring gene STARR-seq mESC enhancer starr_39473 Neighboring gene STARR-seq mESC enhancer starr_39474 Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene STARR-seq mESC enhancer starr_39475 Neighboring gene STARR-seq mESC enhancer starr_39477 Neighboring gene STARR-seq mESC enhancer starr_39478 Neighboring gene microRNA 7648 Neighboring gene ALG10 alpha-1,2-glucosyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-10
    Names
    sytX

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018803.2NP_061273.1  synaptotagmin-10

      See identical proteins and their annotated locations for NP_061273.1

      Status: VALIDATED

      Source sequence(s)
      AC124133, BC125634, CJ093642
      Consensus CDS
      CCDS27756.1
      UniProtKB/Swiss-Prot
      Q9R0N4
      UniProtKB/TrEMBL
      Q059J3
      Related
      ENSMUSP00000029441.4, ENSMUST00000029441.4
      Conserved Domains (2) summary
      cd08385
      Location:231356
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:365498
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89657221..89726181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245696.2XP_011243998.1  synaptotagmin-10 isoform X1

      Conserved Domains (2) summary
      cd08385
      Location:231356
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:365498
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    2. XM_006521175.3XP_006521238.1  synaptotagmin-10 isoform X2

      Conserved Domains (2) summary
      cd08385
      Location:231356
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:365498
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    3. XM_017316706.3XP_017172195.1  synaptotagmin-10 isoform X4

      Conserved Domains (2) summary
      cd08385
      Location:50175
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:184317
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    4. XM_006521176.4XP_006521239.1  synaptotagmin-10 isoform X3

      Conserved Domains (2) summary
      cd08385
      Location:231356
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      COG5038
      Location:142305
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]