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    Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [ Mus musculus (house mouse) ]

    Gene ID: 19185, updated on 27-Nov-2024

    Summary

    Official Symbol
    Psmd4provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 4provided by MGI
    Primary source
    MGI:MGI:1201670
    See related
    Ensembl:ENSMUSG00000005625 AllianceGenome:MGI:1201670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af1; Mcb1; angiocidin
    Summary
    Predicted to enable identical protein binding activity; molecular adaptor activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain; liver; and surface ectoderm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 83.0), placenta adult (RPKM 82.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Psmd4 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94939999..94949880, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95032688..95042614, complement)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    26S proteasome non-ATPase regulatory subunit 4
    Names
    26S proteasome regulatory subunit RPN10
    26S proteasome regulatory subunit S5A
    RPN10 homolog
    anti secretory factor 1
    multiubiquitin chain-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282017.2NP_001268946.1  26S proteasome non-ATPase regulatory subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001268946.1

      Status: VALIDATED

      Source sequence(s)
      AC087062
      Consensus CDS
      CCDS71287.1
      UniProtKB/TrEMBL
      Q3ULG4, Q9CY29
      Related
      ENSMUSP00000071589.6, ENSMUST00000071664.12
      Conserved Domains (1) summary
      cd01452
      Location:1187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    2. NM_001410538.1NP_001397467.1  26S proteasome non-ATPase regulatory subunit 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087062
    3. NM_001410539.1NP_001397468.1  26S proteasome non-ATPase regulatory subunit 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087062
    4. NM_001410540.1NP_001397469.1  26S proteasome non-ATPase regulatory subunit 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087062
    5. NM_001410541.1NP_001397470.1  26S proteasome non-ATPase regulatory subunit 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087062
    6. NM_001410542.1NP_001397471.1  26S proteasome non-ATPase regulatory subunit 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087062
    7. NM_001410543.1NP_001397472.1  26S proteasome non-ATPase regulatory subunit 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087062
    8. NM_008951.3NP_032977.1  26S proteasome non-ATPase regulatory subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_032977.1

      Status: VALIDATED

      Source sequence(s)
      AC087062
      Consensus CDS
      CCDS38541.1
      UniProtKB/Swiss-Prot
      O35226, Q91V59, Q9JJM0, Q9JJM1, Q9JJM2, Q9JJM3
      UniProtKB/TrEMBL
      Q9CY29
      Related
      ENSMUSP00000102857.2, ENSMUST00000107237.8
      Conserved Domains (1) summary
      cd01452
      Location:1187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94939999..94949880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252465.1XP_030108325.1  26S proteasome non-ATPase regulatory subunit 4 isoform X2

      Conserved Domains (2) summary
      NF033415
      Location:202257
      thiovirid_RiPP; thioviridamide family RiPP peptide
      cl00057
      Location:181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_006501137.3XP_006501200.1  26S proteasome non-ATPase regulatory subunit 4 isoform X1

      Conserved Domains (2) summary
      NF033415
      Location:205260
      thiovirid_RiPP; thioviridamide family RiPP peptide
      cl00057
      Location:181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...