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    Mib1 MIB E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 225164, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mib1provided by MGI
    Official Full Name
    MIB E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:2443157
    See related
    Ensembl:ENSMUSG00000024294 AllianceGenome:MGI:2443157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mib; DIP-1; mindbomb; E430019M12Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.8), frontal lobe adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mib1 in Genome Data Viewer
    Location:
    18 A1; 18 5.35 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10725523..10822969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10725625..10818578)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3 Neighboring gene RIKEN cDNA 4930563E18 gene Neighboring gene predicted gene, 25116 Neighboring gene Mir133a-1, Mir1b and Mir1a-2 host gene Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1a-2 Neighboring gene microRNA 1b Neighboring gene STARR-seq mESC enhancer starr_43802 Neighboring gene STARR-seq mESC enhancer starr_43806 Neighboring gene apurinic/apyrimidinic endonuclease 1 pseudogene Neighboring gene predicted gene, 35814 Neighboring gene PHD finger protein 14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1323, MGC18948

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MIB1
    Names
    DAPK-interacting protein-1
    RING-type E3 ubiquitin transferase MIB1
    mind bomb homolog 1
    mindbomb E3 ubiquitin protein ligase 1
    mindbomb homolog 1
    skeletrophin
    NP_001351926.1
    NP_659109.2
    XP_006525874.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364997.1NP_001351926.1  E3 ubiquitin-protein ligase MIB1

      Status: VALIDATED

      Source sequence(s)
      AC105947, AC140316
      Consensus CDS
      CCDS29058.1
      UniProtKB/Swiss-Prot
      Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
      UniProtKB/TrEMBL
      A2RRJ6
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain
    2. NM_144860.3NP_659109.2  E3 ubiquitin-protein ligase MIB1

      See identical proteins and their annotated locations for NP_659109.2

      Status: VALIDATED

      Source sequence(s)
      AC140316, AY245539
      Consensus CDS
      CCDS29058.1
      UniProtKB/Swiss-Prot
      Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
      UniProtKB/TrEMBL
      A2RRJ6
      Related
      ENSMUSP00000054428.5, ENSMUST00000052838.11
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10725523..10822969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525811.5XP_006525874.1  E3 ubiquitin-protein ligase MIB1 isoform X1

      See identical proteins and their annotated locations for XP_006525874.1

      UniProtKB/Swiss-Prot
      Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
      UniProtKB/TrEMBL
      A2RRJ6
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain

    RNA

    1. XR_004939841.1 RNA Sequence

    2. XR_004939840.1 RNA Sequence

    3. XR_004939842.1 RNA Sequence