Cyb561a3 cytochrome b561 family, member A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyb561a3provided by MGI
Official Full Name: cytochrome b561 family, member A3provided by MGI
Primary source: MGI:MGI:2686925
See related: Ensembl:ENSMUSG00000034445 AllianceGenome:MGI:2686925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lcytb; Cybasc3; 2310004G04Rik
Summary: Enables transmembrane ascorbate ferrireductase activity. Involved in intracellular iron ion homeostasis. Located in late endosome membrane and lysosomal membrane. Is expressed in ganglia; jaw bone; and neural retina. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 58.0), lung adult (RPKM 24.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.6 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10554521..10574196)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10577157..10596832)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane ascorbate ferrireductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

Names: cytochrome b ascorbate-dependent protein 3; lysosomal cytochrome b

NP_001268993.1

EC 7.2.1.3

NP_001268994.1

EC 7.2.1.3

NP_001268996.1

EC 7.2.1.3

NP_001349359.1

EC 7.2.1.3

NP_001349360.1

EC 7.2.1.3

NP_958739.1

EC 7.2.1.3

XP_006527001.1

EC 7.2.1.3

XP_006527002.1

EC 7.2.1.3

XP_006527003.1

EC 7.2.1.3

XP_017173636.1

EC 7.2.1.3

XP_030106739.1

EC 7.2.1.3

XP_030106742.1

EC 7.2.1.3

XP_030106743.1

EC 7.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282064.1 → NP_001268993.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

See identical proteins and their annotated locations for NP_001268993.1

Status: VALIDATED

Source sequence(s)

AC125093, AK139533, AK168841, BY387699

Consensus CDS

CCDS29582.1

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Related

ENSMUSP00000157672.2, ENSMUST00000235271.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_001282065.1 → NP_001268994.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2

See identical proteins and their annotated locations for NP_001268994.1

Status: VALIDATED

Source sequence(s)

AC125093, AK139533, AK160179, AK168841, BY387699

Consensus CDS

CCDS89344.1

UniProtKB/Swiss-Prot

Q6P1H1

Related

ENSMUSP00000157602.2, ENSMUST00000237641.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_001282067.2 → NP_001268996.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

See identical proteins and their annotated locations for NP_001268996.1

Status: VALIDATED

Source sequence(s)

AK139533, AK168841, BY387699

Consensus CDS

CCDS29582.1

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Related

ENSMUSP00000157884.2, ENSMUST00000237581.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_001362430.1 → NP_001349359.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

Status: VALIDATED

Source sequence(s)

AC125093

Consensus CDS

CCDS29582.1

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Related

ENSMUSP00000130680.2, ENSMUST00000168445.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_001362431.1 → NP_001349360.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

Status: VALIDATED

Source sequence(s)

AC125093

Consensus CDS

CCDS29582.1

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_201351.2 → NP_958739.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

See identical proteins and their annotated locations for NP_958739.1

Status: VALIDATED

Source sequence(s)

AC125093, AK139533, AK168841, BY387699

Consensus CDS

CCDS29582.1

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Related

ENSMUSP00000158186.2, ENSMUST00000237814.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10554521..10574196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526940.4 → XP_006527003.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X2

See identical proteins and their annotated locations for XP_006527003.1

UniProtKB/Swiss-Prot

Q6P1H1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_030250883.2 → XP_030106743.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_017318147.3 → XP_017173636.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

Related

ENSMUSP00000157892.2, ENSMUST00000236352.2

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_006526938.5 → XP_006527001.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

See identical proteins and their annotated locations for XP_006527001.1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_030250879.1 → XP_030106739.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_006526939.5 → XP_006527002.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

See identical proteins and their annotated locations for XP_006527002.1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_030250882.2 → XP_030106742.1 lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

UniProtKB/Swiss-Prot

Q3TVE2, Q3V3G2, Q6P1H1

Conserved Domains (1) summary

cl23723
Location:10 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...