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    Alg10b ALG10 alpha-1,2-glucosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 380959, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alg10bprovided by MGI
    Official Full Name
    ALG10 alpha-1,2-glucosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2146159
    See related
    Ensembl:ENSMUSG00000075470 AllianceGenome:MGI:2146159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nse5; Deaf1; Gm917
    Summary
    Predicted to enable dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity. Acts upstream of or within auditory receptor cell development and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in long QT syndrome 2. Orthologous to human ALG10 (ALG10 alpha-1,2-glucosyltransferase) and ALG10B (ALG10 alpha-1,2-glucosyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.4), CNS E11.5 (RPKM 12.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Alg10b in Genome Data Viewer
    Location:
    15 E3; 15 45.07 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (90108506..90117674)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (90224311..90230554)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin X Neighboring gene STARR-seq mESC enhancer starr_39472 Neighboring gene STARR-seq mESC enhancer starr_39473 Neighboring gene STARR-seq mESC enhancer starr_39474 Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene STARR-seq mESC enhancer starr_39475 Neighboring gene STARR-seq mESC enhancer starr_39477 Neighboring gene STARR-seq mESC enhancer starr_39478 Neighboring gene microRNA 7648 Neighboring gene predicted gene, 36480 Neighboring gene STARR-seq mESC enhancer starr_39480 Neighboring gene WEE1 homolog 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    Names
    alpha-1,2-glucosyltransferase ALG10-A
    alpha-2-glucosyltransferase ALG10-B
    asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)
    asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)
    asparagine-linked glycosylation protein 10 homolog B
    potassium channel regulator 1
    putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    putative alpha-1,2-glucosyltransferase ALG10-B
    NP_001028613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033441.4NP_001028613.1  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

      See identical proteins and their annotated locations for NP_001028613.1

      Status: VALIDATED

      Source sequence(s)
      AC158922
      Consensus CDS
      CCDS27757.1
      UniProtKB/Swiss-Prot
      Q3TLS4, Q3UGP8
      UniProtKB/TrEMBL
      Q3UPY7
      Related
      ENSMUSP00000097882.2, ENSMUST00000100309.3
      Conserved Domains (1) summary
      pfam04922
      Location:33428
      DIE2_ALG10; DIE2/ALG10 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      90108506..90117674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)