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    Strn striatin, calmodulin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 268980, updated on 9-Dec-2024

    Summary

    Official Symbol
    Strnprovided by MGI
    Official Full Name
    striatin, calmodulin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1333757
    See related
    Ensembl:ENSMUSG00000024077 AllianceGenome:MGI:1333757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130055P19
    Summary
    Predicted to enable several functions, including armadillo repeat domain binding activity; calmodulin binding activity; and nuclear estrogen receptor binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; dendrite development; and locomotory behavior. Predicted to be located in several cellular components, including bicellular tight junction; dendritic spine; and postsynaptic membrane. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in central nervous system and retina. Orthologous to human STRN (striatin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.6), cortex adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Strn in Genome Data Viewer
    Location:
    17 49.54 cM; 17 E3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (78957327..79043990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78649898..78737322, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 1, pseudogene Neighboring gene predicted gene, 32573 Neighboring gene vitrin Neighboring gene STARR-seq mESC enhancer starr_43270 Neighboring gene STARR-positive B cell enhancer ABC_E1201 Neighboring gene ubiquitin-conjugating enzyme E2C pseudogene Neighboring gene HEAT repeat containing 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables armadillo repeat domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of FAR/SIN/STRIPAK complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413756.1NP_001400685.1  striatin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151284
    2. NM_011500.3NP_035630.2  striatin isoform 1

      See identical proteins and their annotated locations for NP_035630.2

      Status: VALIDATED

      Source sequence(s)
      AC151284, BC090968
      Consensus CDS
      CCDS28978.1
      UniProtKB/Swiss-Prot
      B2RWV9, O55106, Q5BKR9
      UniProtKB/TrEMBL
      Q3UWX9
      Related
      ENSMUSP00000120830.3, ENSMUST00000145910.9
      Conserved Domains (4) summary
      COG2319
      Location:449778
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:455779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:48173
      Striatin; Striatin family
      sd00039
      Location:468514
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      78957327..79043990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160632.1XP_036016525.1  striatin isoform X2

      UniProtKB/TrEMBL
      F8WH41
      Related
      ENSMUSP00000024881.8, ENSMUST00000024881.14
      Conserved Domains (2) summary
      cd00200
      Location:267591
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:280326
      7WD40; WD40 repeat [structural motif]