Arf3 ARF GTPase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arf3provided by MGI
Official Full Name: ARF GTPase 3provided by MGI
Primary source: MGI:MGI:99432
See related: Ensembl:ENSMUSG00000051853 AllianceGenome:MGI:99432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5430400P17Rik
Summary: Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ARF3 (ADP ribosylation factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 216.8), cortex adult (RPKM 209.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98635505..98660999, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98737624..98763118, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
Title: Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
ARF3 promotes breast cancer cell proliferation through the participation of FOXO1.
Title: Up-regulated ADP-Ribosylation factor 3 promotes breast cancer cell proliferation through the participation of FOXO1.
activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex.
Title: ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

Arf3 (e-PCR), detects polymorphism
- UniSTS:506736

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	TAS Traceable Author Statement more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribosylation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355510.1 → NP_001342439.1 ADP-ribosylation factor 3

Status: VALIDATED

Source sequence(s)

AC156543

Consensus CDS

CCDS27804.1

UniProtKB/Swiss-Prot

P61205

UniProtKB/TrEMBL

Q3U344

Conserved Domains (1) summary

cl38936
Location:5 → 179

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_007478.3 → NP_031504.1 ADP-ribosylation factor 3

See identical proteins and their annotated locations for NP_031504.1

Status: VALIDATED

Source sequence(s)

AC156543

Consensus CDS

CCDS27804.1

UniProtKB/Swiss-Prot

P61205

UniProtKB/TrEMBL

Q3U344

Related

ENSMUSP00000050689.10, ENSMUST00000053183.12

Conserved Domains (1) summary

cl38936
Location:5 → 179

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases