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    Fam72a family with sequence similarity 72, member A [ Mus musculus (house mouse) ]

    Gene ID: 108900, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fam72aprovided by MGI
    Official Full Name
    family with sequence similarity 72, member Aprovided by MGI
    Primary source
    MGI:MGI:1919669
    See related
    Ensembl:ENSMUSG00000055184 AllianceGenome:MGI:1919669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P17; 2700049P18Rik
    Summary
    Predicted to act upstream of or within negative regulation of brain-derived neurotrophic factor-activated receptor activity and positive regulation of apoptotic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in cytosol. Is expressed in brain; esophagus; genitourinary system; and trachea. Orthologous to several human genes including FAM72A (family with sequence similarity 72 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.7), liver E14 (RPKM 1.8) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fam72a in Genome Data Viewer
    Location:
    1 E4; 1 56.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131454336..131466773)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131526598..131539035)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10034 Neighboring gene inhibitor of kappaB kinase epsilon Neighboring gene predicted gene, 51644 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5796 Neighboring gene STARR-positive B cell enhancer ABC_E5797 Neighboring gene predicted gene, 53252 Neighboring gene STARR-seq mESC enhancer starr_02218 Neighboring gene STARR-positive B cell enhancer ABC_E23 Neighboring gene STARR-positive B cell enhancer ABC_E8941 Neighboring gene STARR-positive B cell enhancer ABC_E5798 Neighboring gene STARR-seq mESC enhancer starr_02220 Neighboring gene STARR-positive B cell enhancer ABC_E11085 Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

    Clone Names

    • MGC117955

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175382.5NP_780591.1  protein FAM72A

      See identical proteins and their annotated locations for NP_780591.1

      Status: VALIDATED

      Source sequence(s)
      AC120217
      Consensus CDS
      CCDS15270.1
      UniProtKB/Swiss-Prot
      B2RR49, Q3KQN3, Q8BFZ8
      Related
      ENSMUSP00000068111.5, ENSMUST00000068613.5
      Conserved Domains (1) summary
      pfam14976
      Location:5149
      FAM72; FAM72 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131454336..131466773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255524.2XP_030111384.1  protein FAM72A isoform X1

      Conserved Domains (1) summary
      pfam14976
      Location:576
      FAM72; FAM72 protein