Stag3 STAG3 cohesin complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stag3provided by MGI
Official Full Name: STAG3 cohesin complex componentprovided by MGI
Primary source: MGI:MGI:1355311
See related: Ensembl:ENSMUSG00000036928 AllianceGenome:MGI:1355311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SA-2
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Located in lateral element; male germ cell nucleus; and transverse filament. Part of meiotic cohesin complex. Is expressed in bone marrow; brain; and genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8 and spermatogenic failure 61. Orthologous to human STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 51.9), CNS E18 (RPKM 4.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 77.01 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138270757..138310659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138272514..138312397)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STAG3 deficiency has a major effect on DNA double-strand breaks number even in the absence of PRDM9, showing that its role is not restricted to canonical PRDM9-activated hotspots.
Title: Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation.
Title: Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.
our data suggests that STAG3 is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis.
Title: Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes.
STAG3 is a strong candidate gene for male infertility
Title: STAG3 is a strong candidate gene for male infertility.
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
Title: STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin.
Title: Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion.
E2F6 silences SMC1beta and STAG3 in somatic cells
Title: Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stag3 (e-PCR), detects polymorphism
- UniSTS:546566

Stag3 (e-PCR), detects polymorphism
- UniSTS:164699

AJ005678 (e-PCR)
- UniSTS:179300

AJ005678 (e-PCR)
- UniSTS:159464

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of meiotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of meiotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within female meiosis sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of meiotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic cohesin complex	IDA Inferred from Direct Assay more info	PubMed
part_of meiotic cohesin complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in transverse filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cohesin subunit SA-3

Names: SCC3 homolog 3; stromal antigen 3; stromalin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.