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    PF3D7_1311800 M1-family alanyl aminopeptidase [ Plasmodium falciparum 3D7 ]

    Gene ID: 813945, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1311800
    Gene description
    M1-family alanyl aminopeptidase
    Locus tag
    PF3D7_1311800
    See related
    PlasmoDB:PF3D7_1311800; VEuPathDB:PF3D7_1311800
    Gene type
    protein coding
    RNA name
    M1-family alanyl aminopeptidase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1311800 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (501790..505047)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene cytochrome c, putative Neighboring gene V-type proton ATPase catalytic subunit A Neighboring gene malonyl CoA-acyl carrier protein transacylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Plasmodium falciparum M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development. Hoff CC, et al. Pathogens, 2021 Nov 10. PMID 34832608, Free PMC Article
    2. Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1. Yang W, et al. ChemMedChem, 2018 Dec 6. PMID 30318749
    3. Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism. Ragheb D, et al. J Biol Chem, 2011 Aug 5. PMID 21659511, Free PMC Article
    4. Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. Azimzadeh O, et al. Malar J, 2010 Jun 30. PMID 20591164, Free PMC Article
    5. Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. Flipo M, et al. J Med Chem, 2007 Mar 22. PMID 17326615

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The evaluation of a highly selective inhibitor of PfA-M1, over PfA-M17, active on Plasmodium parasites in vitro and in vivo, highlights the relevance of PfA-M1 in the biological development of the parasite as well as in the list of promising anti-malarial targets to be considered in combination with current or future anti-malarial drugs.
      Title: Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
    2. results provide insights on PfA-M1 topology regarding key compartments of the infected red blood cells implications for the development of inhibitors targeting this plasmodial enzyme.
      Title: Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole.
    3. Data suggest that detailed understanding of the PfA-M1 and PfA-M17 active sites permits a rational approach in the development of a unique class of two-target and/or combination antimalarial therapy.
      Title: Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in food vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    M1-family alanyl aminopeptidase
    XP_001349846.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      501790..505047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349810.1 → XP_001349846.1  M1-family alanyl aminopeptidase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349846.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O96935, Q8IEK1
      UniProtKB/TrEMBL
      A0A024V3R7, A0A024VLR0, A0A024W498, A0A024WKQ2, A0A024X460, A0A0L1I8Z4, A0A0L7LXM8, W4ICL0, W4IZJ4, W7FDG8, W7FHH8, W7JJ17, W7K2M2
      Conserved Domains (1) summary
      TIGR02414
      Location:203 → 1082
      pepN_proteo; aminopeptidase N, Escherichia coli type
    Nucleotide Protein
    Heading Accession and Version

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