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    PF3D7_1301600 erythrocyte binding antigen-140 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813949, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1301600
    Gene description
    erythrocyte binding antigen-140
    Locus tag
    PF3D7_1301600
    See related
    PlasmoDB:PF3D7_1301600; VEuPathDB:PF3D7_1301600
    Gene type
    protein coding
    RNA name
    erythrocyte binding antigen-140
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1301600 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    4
    Sequence:
    Chromosome: 13; NC_004331.3 (89319..93352, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene Plasmodium exported protein (hyp12), unknown function Neighboring gene Plasmodium exported protein (PHISTa), unknown function Neighboring gene CX3CL1-binding protein 2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140. Salinas ND, et al. Infect Immun, 2019 Apr. PMID 30642904, Free PMC Article
    2. Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL. Malpede BM, et al. J Biol Chem, 2013 Apr 26. PMID 23508963, Free PMC Article
    3. Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion. Lin DH, et al. J Biol Chem, 2012 Oct 26. PMID 22989878, Free PMC Article
    4. Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. Cortés A, et al. PLoS Pathog, 2007 Aug 3. PMID 17676953, Free PMC Article
    5. A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes. Thompson JK, et al. Mol Microbiol, 2001 Jul. PMID 11454199

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunization of mice with the functionally relevant F1 domain of EBA-140 results in antibodies that confer a 2-fold increase in parasite neutralization compared to that of the F2 domain.
      Title: Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140.
    2. Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL.
      Title: Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL.
    3. Insight into the structural basis and mechanism of Plasmodium falciparum erythrocyte-binding antigen-140 receptor engagement.
      Title: Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion.
    4. Polymorphisms affect the levels of EBA-140 binding to receptors but, critically, not the receptor specificity of this protein.
      Title: Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum.
    5. Silencing was clonally transmitted and occurred in the absence of detectable DNA alterations, suggesting that it is epigenetic. This was demonstrated for eba-140.
      Title: Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables host cell surface receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    erythrocyte binding antigen-140

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      89319..93352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349823.1 → XP_001349859.1  erythrocyte binding antigen-140 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349859.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V378, A0A024WKU0, A0A2I0BW58, Q76NM5, Q8WS31
      Conserved Domains (3) summary
      PTZ00176
      Location:167 → 690
      PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
      PTZ00121
      Location:558 → 1203
      PTZ00121; MAEBL; Provisional
      pfam11556
      Location:1046 → 1126
      EBA-175_VI; Erythrocyte binding antigen 175
    Nucleotide Protein
    Heading Accession and Version

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