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    PF3D7_1117800 DNA mismatch repair protein MLH [ Plasmodium falciparum 3D7 ]

    Gene ID: 810731, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1117800
    Gene description
    DNA mismatch repair protein MLH
    Locus tag
    PF3D7_1117800
    See related
    PlasmoDB:PF3D7_1117800; VEuPathDB:PF3D7_1117800
    Gene type
    protein coding
    RNA name
    DNA mismatch repair protein MLH
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1117800 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    1
    Sequence:
    Chromosome: 11; NC_037282.1 (674299..677349, complement)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene peptidyl-tRNA hydrolase ICT1 Neighboring gene GTP-binding nuclear protein RAN/TC4 Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasmodium falciparum MLH is schizont stage specific endonuclease. Tarique M, et al. Mol Biochem Parasitol, 2012 Feb. PMID 22079692
    2. Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. Ahmad M, et al. PLoS One, 2012. PMID 23185322, Free PMC Article
    3. PfAP2Tel, harbouring a non-canonical DNA-binding AP2 domain, binds to Plasmodium falciparum telomeres. Sierra-Miranda M, et al. Cell Microbiol, 2017 Sep. PMID 28376558
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mismatch repair ISM
    Inferred from Sequence Model
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein MLH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      674299..677349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347819.1 → XP_001347855.1  DNA mismatch repair protein MLH [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347855.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024X645, A0A0L1ICN9, A0A2I0C0I9, Q86G82, Q8IIJ0, W4IRW3
      Conserved Domains (3) summary
      COG0323
      Location:49 → 650
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
      cd16926
      Location:58 → 238
      HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains
      pfam16413
      Location:710 → 1016
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    Nucleotide Protein
    Heading Accession and Version

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