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    PF3D7_1335900 thrombospondin-related anonymous protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 814170, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1335900
    Gene description
    thrombospondin-related anonymous protein
    Locus tag
    PF3D7_1335900
    See related
    PlasmoDB:PF3D7_1335900; VEuPathDB:PF3D7_1335900
    Gene type
    protein coding
    RNA name
    thrombospondin-related anonymous protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1335900 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (1464895..1466619, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved oligomeric Golgi complex subunit 3, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates. Mehrizi AA, et al. Infect Genet Evol, 2020 Jun. PMID 31954917
    2. Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand. Ohashi J, et al. PLoS One, 2014. PMID 24587387, Free PMC Article
    3. TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Sultan AA, et al. Cell, 1997 Aug 8. PMID 9267031
    4. Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum: expression during sporozoite ontogeny and binding to human hepatocytes. Robson KJ, et al. EMBO J, 1995 Aug 15. PMID 7664729, Free PMC Article
    5. Characterization of Plasmodium falciparum sporozoite surface protein 2. Rogers WO, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409621, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Platelet derived growth factor receptor beta (PDGFRbeta) is a host receptor for the human malaria parasite adhesin TRAP.
      Title: Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.
    2. Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates.
      Title: Population genetic structure analysis of thrombospondin-related adhesive protein (TRAP) as a vaccine candidate antigen in worldwide Plasmodium falciparum isolates.
    3. The identification of the integrin alphavbeta3 as the host receptor for TRAP provides an important demonstration of a sporozoite surface ligand that directly interacts with host receptors.
      Title: Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.
    4. The circumsporozoite protein (CSP) and the thrombospondin-related anonymous protein (TRAP) bind to the heparan sulfate proteoglycan on the hepatocyte surface and contribute to sporozoite infection and hepatocyte selectivity.
      Title: Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes.
    5. The molecular flexibility and the multimeric nature of aldolase are both critical for its interactions with both TRAP and actin in the invasion machinery
      Title: Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
    6. Used a large compound library to study candidate compounds that stabilize and prevent the disassembly of the PfAldolase-TRAP complex of the glideosome.
      Title: Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
    7. Results suggest that the thrombospondin-related adhesive protein (TRAP) molecule is a major target of the human immune response to pre-erythrocytic stages.
      Title: Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables host cell surface receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell gliding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thrombospondin-related anonymous protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1464895..1466619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350052.1 → XP_001350088.1  thrombospondin-related anonymous protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350088.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5Q2EZD7, Q26020, Q76NM2, W7K193
      Conserved Domains (1) summary
      PTZ00441
      Location:1 → 574
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    Nucleotide Protein
    Heading Accession and Version

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