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    PF3D7_1408100 plasmepsin III [ Plasmodium falciparum 3D7 ]

    Gene ID: 811660, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1408100
    Gene description
    plasmepsin III
    Locus tag
    PF3D7_1408100
    See related
    PlasmoDB:PF3D7_1408100; VEuPathDB:PF3D7_1408100
    Gene type
    protein coding
    RNA name
    plasmepsin III
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1408100 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    1
    Sequence:
    Chromosome: 14; NC_037283.1 (297468..298823)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene plasmepsin I Neighboring gene plasmepsin II Neighboring gene AP2 domain transcription factor AP2-G2, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum. Bhaumik P, et al. Biochemistry, 2011 Oct 18. PMID 21928835, Free PMC Article
    2. Characterization of the monomer-dimer equilibrium of recombinant histo-aspartic protease from Plasmodium falciparum. Xiao H, et al. Mol Biochem Parasitol, 2010 Sep. PMID 20435072
    3. Recombinant expression and partial characterization of an active soluble histo-aspartic protease from Plasmodium falciparum. Xiao H, et al. Protein Expr Purif, 2006 Sep. PMID 16624575
    4. Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum. Bopp S, et al. Nat Commun, 2018 May 2. PMID 29720620, Free PMC Article
    5. Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study. Amato R, et al. Lancet Infect Dis, 2017 Feb. PMID 27818095, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased copy number for plasmepsin II and plasmepsin III appears to enhanced survival when exposed to piperaquine (PPQ).
      Title: Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.
    2. structural analysis of activation and inhibition of histo-aspartic protease from Plasmodium falciparum
      Title: Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.
    3. HAP was most active as a monomer.
      Title: Characterization of the monomer-dimer equilibrium of recombinant histo-aspartic protease from Plasmodium falciparum.
    4. partial characterization of an active soluble histo-aspartic protease from Plasmodium falciparum
      Title: Recombinant expression and partial characterization of an active soluble histo-aspartic protease from Plasmodium falciparum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in food vacuole HDA PubMed 
    located_in food vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasmepsin III
    XP_001348251.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      297468..298823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348215.1 → XP_001348251.1  plasmepsin III [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0L7K5R8, Q8IM15, Q9Y006
      UniProtKB/TrEMBL
      A0A024V0A2, A0A024VFA4, A0A024W273, A0A024WI96, A0A024X0M6, W4IBC9, W4IV73, W7F1X2, W7FGC6, W7J6P8, W7K8T5
      Conserved Domains (1) summary
      PTZ00147
      Location:1 → 449
      PTZ00147; plasmepsin-1; Provisional
    Nucleotide Protein
    Heading Accession and Version

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