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    PF3D7_1419300 glutathione S-transferase [ Plasmodium falciparum 3D7 ]

    Gene ID: 811768, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1419300
    Gene description
    glutathione S-transferase
    Locus tag
    PF3D7_1419300
    See related
    PlasmoDB:PF3D7_1419300; VEuPathDB:PF3D7_1419300
    Gene type
    protein coding
    RNA name
    glutathione S-transferase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1419300 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    2
    Sequence:
    Chromosome: 14; NC_037283.1 (802717..803481)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene ATP-dependent rRNA helicase SPB4, putative Neighboring gene thioredoxin-like protein, putative Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound. Colón-Lorenzo EE, et al. Front Pharmacol, 2020. PMID 32256353, Free PMC Article
    2. Asn112 in Plasmodium falciparum glutathione S-transferase is essential for induced reversible tetramerization by phosphate or pyrophosphate. Quesada-Soriano I, et al. Biochim Biophys Acta, 2014 Sep. PMID 24792386
    3. Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119. Liebau E, et al. J Biol Chem, 2009 Aug 14. PMID 19531494, Free PMC Article
    4. Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum. Liebau E, et al. J Biol Chem, 2005 Jul 15. PMID 15888443
    5. Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target. Harwaldt P, et al. Biol Chem, 2002 May. PMID 12108547

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asparagine 112 in Plasmodium falciparum glutathione S-transferase is essential for induced reversible tetramerization by phosphate or pyrophosphate.
      Title: Asn112 in Plasmodium falciparum glutathione S-transferase is essential for induced reversible tetramerization by phosphate or pyrophosphate.
    2. protection by PfGST against hemin is independent of the redox status of the parasite cell
      Title: Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.
    3. PfGST evolved by optimizing its binding property with the parasitotoxic hemin rather than its catalytic efficiency toward toxic electrophilic compounds
      Title: Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase
    XP_001348360.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      802717..803481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348324.1 → XP_001348360.1  glutathione S-transferase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348360.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A144A1J6, Q8ILQ7, Q8MU52, Q95V54
      UniProtKB/TrEMBL
      A0A024V1C7, A0A024VL02, A0A024W1R6, A0A024WV71, A0A024X1P1, W4I8T1, W4IVI0, W7FES3, W7FLF0, W7J689, W7JY33
      Conserved Domains (1) summary
      PTZ00057
      Location:1 → 211
      PTZ00057; glutathione s-transferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ILQ7.1

    Gene LinkOut

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