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    PF3D7_0202000 knob-associated histidine-rich protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 812616, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0202000
    Gene description
    knob-associated histidine-rich protein
    Locus tag
    PF3D7_0202000
    See related
    PlasmoDB:PF3D7_0202000; VEuPathDB:PF3D7_0202000
    Gene type
    protein coding
    RNA name
    knob-associated histidine-rich protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0202000 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_037280.1 (103385..105796, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene knob associated heat shock protein 40 Neighboring gene erythrocyte membrane protein 3 Neighboring gene liver stage associated protein 2 Neighboring gene EMP1-trafficking protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tetracysteine-based fluorescent tags to study protein localization and trafficking in Plasmodium falciparum-infected erythrocytes. Crivat G, et al. PLoS One, 2011. PMID 21860664, Free PMC Article
    2. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Crabb BS, et al. Cell, 1997 Apr 18. PMID 9108483
    3. Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin. Pei X, et al. J Biol Chem, 2005 Sep 2. PMID 16006556
    4. The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes. Rug M, et al. Blood, 2006 Jul 1. PMID 16507777, Free PMC Article
    5. Genetic polymorphism at the C-terminal domain (region III) of knob-associated histidine-rich protein (KAHRP) of Plasmodium falciparum in isolates from Iran. Mardani A, et al. Parasitol Res, 2011 Dec. PMID 21594767

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) with erythrocyte ankyrin R is required for its attachment to the erythrocyte membrane.
      Title: Interaction of Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) with erythrocyte ankyrin R is required for its attachment to the erythrocyte membrane.
    2. three allelic types were observed at the C-terminal domain of KAHRP of Plasmodium falciparum in isolates from Iran
      Title: Genetic polymorphism at the C-terminal domain (region III) of knob-associated histidine-rich protein (KAHRP) of Plasmodium falciparum in isolates from Iran.
    3. Thus, loss of functional REX1 directly or indirectly ablates the assembly of the Plasmodium falciparum virulence complex, including PfEMP1 and KAHRP, at the surface of host erythrocytes.
      Title: Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex.
    4. The 5' repeat region of KAHRP is important in cross-linking to the host-cell cytoskeleton and this is required for knob protrusion and efficient adhesion under physiologic flow conditions
      Title: The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes.
    5. Results suggest that the interaction of KAHRP with spectrin is critical for appropriate membrane localization of KAHRP in parasitized erythrocytes.
      Title: Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to microvasculature IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in infected host cell surface knob IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    knob-associated histidine-rich protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      103385..105796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349498.3 → XP_001349534.1  knob-associated histidine-rich protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349534.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L1ICB9, A0A2I0BVB8, Q9TY99
      Conserved Domains (2) summary
      PTZ00121
      Location:399 → 595
      PTZ00121; MAEBL; Provisional
      pfam17986
      Location:149 → 195
      EKAL; EMP3-KAHRP-like N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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