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    PF3D7_0207000 merozoite surface protein 4 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812662, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0207000
    Gene description
    merozoite surface protein 4
    Locus tag
    PF3D7_0207000
    See related
    PlasmoDB:PF3D7_0207000; VEuPathDB:PF3D7_0207000
    Gene type
    protein coding
    RNA name
    merozoite surface protein 4
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0207000 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_037280.1 (277494..278456, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene merozoite surface protein 2 Neighboring gene merozoite surface protein 5 Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene iron-sulfur assembly protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association of antibodies to Plasmodium falciparum merozoite surface protein-4 with protection against clinical malaria. Perraut R, et al. Vaccine, 2017 Dec 4. PMID 29042203
    2. Identifying merozoite surface protein 4 and merozoite surface protein 7 Plasmodium falciparum protein family members specifically binding to human erythrocytes suggests a new malarial parasite-redundant survival mechanism. Garcia Y, et al. J Med Chem, 2007 Nov 15. PMID 17944453
    3. Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum. Gilson PR, et al. Mol Cell Proteomics, 2006 Jul. PMID 16603573
    4. A network-based approach reveals novel invasion and Maurer's clefts-related proteins in Plasmodium falciparum. Das D, et al. Mol Omics, 2019 Dec 2. PMID 31631203
    5. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science, 1998 Nov 6. PMID 9804551

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data are consistent with a protective role for the naturally acquired anti-MSP4 antibodies and support further development of MSP4 as a candidate component of malaria vaccine.
      Title: Association of antibodies to Plasmodium falciparum merozoite surface protein-4 with protection against clinical malaria.
    2. Structural characteristics found when comparing the MSP-4 HABP with MSP-HABPs suggested that these redundant MSP-family proteins could be a new parasite strategy for evading host genetic variability and immune pressure.
      Title: Identifying merozoite surface protein 4 and merozoite surface protein 7 Plasmodium falciparum protein family members specifically binding to human erythrocytes suggests a new malarial parasite-redundant survival mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merozoite surface protein 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      277494..278456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349544.1 → XP_001349580.1  merozoite surface protein 4 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349580.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VCW7, A0A0L7K6K8, O76244, Q7KWJ2, Q8ITL8, Q8T7T5, Q8T7T9, Q8T7U3, Q8T7U6, Q8T7U7, W4INS6, W7KDD0
      Conserved Domains (1) summary
      pfam14670
      Location:207 → 238
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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